Multicomponent Reaction Discovery: Three-Component Synthesis of Spirooxindoles

被引：119

作者：

Liang, Bo

Kalidindi, Srinivas

Porco, John A., Jr.

Stephenson, Corey R. J. ^{[1
]}

机构：

[1] Boston Univ, Dept Chem, Boston, MA 02215 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 03期

关键词：

ASYMMETRIC TOTAL-SYNTHESIS; 2H-INDOL-2-ONE RING-SYSTEM; SPIROTRYPROSTATIN-A; OXINDOLES; PRODUCTS; CONCISE; ANALOGS; FACILE; ACID; DNA;

D O I：

10.1021/ol902764k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Lewis acid-catalyzed, three-component reaction of isatin and two 1,3-dicarbonyl compounds is reported. Reactions proceed with high efficiency under mild reaction conditions and with good functional group tolerance to afford spirooxindole pyranochromenedione derivatives.

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页码：572 / 575

页数：4

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