Concise review: Understanding and leveraging cell metabolism to enhance mesenchymal stem cell transplantation survival in tissue engineering and regenerative medicine applications

被引：82
作者：
Salazar-Noratto, Giuliana E. [1 ,2 ]
Luo, Guotian [1 ,2 ]
Denoeud, Cyprien [1 ,2 ]
Padrona, Mathilde [1 ,2 ]
Moya, Adrien [3 ,4 ,5 ]
Bensidhoum, Morad [1 ,2 ]
Bizios, Rena [6 ]
Potier, Esther [1 ,2 ]
Logeart-Avramoglou, Delphine [1 ,2 ]
Petite, Herve [1 ,2 ]
机构：
[1] Univ Paris, B3OA, CNRS, INSERM, Paris, France
[2] Ecole Natl Vet Alfort, B3OA, Maisons Alfort, France
[3] South Florida Vet Affairs Fdn Res & Educ Inc, Miami, FL USA
[4] Bruce W Carter VAMC, Educ & Clin Ctr, Geriatr Res, Miami, FL USA
[5] Bruce W Carter VAMC, Res Serv, Miami, FL USA
[6] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA
来源：
STEM CELLS | 2020年 / 38卷 / 01期
关键词：
bioenergetics; cell-based therapies; cell delivery and transplantation; cell survival; mesenchymal stem cells; metabolism; multipotent stromal cells; skeletal stem cells; tissue engineering and regenerative medicine; ENDOPLASMIC-RETICULUM STRESS; MARROW STROMAL CELLS; SHOCK-PROTEIN; 27; BONE-MARROW; IN-VITRO; OSTEOGENIC DIFFERENTIATION; THERAPEUTIC-EFFICACY; OXYGEN-CONSUMPTION; ENERGY-METABOLISM; INFARCTED HEART;
D O I：
10.1002/stem.3079
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
In tissue engineering and regenerative medicine, stem cell-specifically, mesenchymal stromal/stem cells (MSCs)-therapies have fallen short of their initial promise and hype. The observed marginal, to no benefit, success in several applications has been attributed primarily to poor cell survival and engraftment at transplantation sites. MSCs have a metabolism that is flexible enough to enable them to fulfill their various cellular functions and remarkably sensitive to different cellular and environmental cues. At the transplantation sites, MSCs experience hostile environments devoid or, at the very least, severely depleted of oxygen and nutrients. The impact of this particular setting on MSC metabolism ultimately affects their survival and function. In order to develop the next generation of cell-delivery materials and methods, scientists must have a better understanding of the metabolic switches MSCs experience upon transplantation. By designing treatment strategies with cell metabolism in mind, scientists may improve survival and the overall therapeutic potential of MSCs. Here, we provide a comprehensive review of plausible metabolic switches in response to implantation and of the various strategies currently used to leverage MSC metabolism to improve stem cell-based therapeutics. Stem Cells 2019
引用
收藏
页码：22 / 33
页数：12
相关论文
共 113 条
[61]   Intracoronary bone marrow cell transfer after myocardial infarction - Eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial [J].
Meyer, GP ;
Wollert, KC ;
Lotz, J ;
Steffens, J ;
Lippolt, P ;
Fichtner, S ;
Hecker, H ;
Schaefer, A ;
Arseniev, L ;
Hertenstein, B ;
Ganser, A ;
Drexler, H .
CIRCULATION, 2006, 113 (10) :1287-1294
[62]   Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche [J].
Mohyeldin, Ahmed ;
Garzon-Muvdi, Tomas ;
Quinones-Hinojosa, Alfredo .
CELL STEM CELL, 2010, 7 (02) :150-161
[63]   Kinetics of thermally induced heat shock protein 27 and 70 expression by bone marrow-derived mesenchymal stem cells [J].
Moloney, Teresa C. ;
Hoban, Deirdre B. ;
Barry, Frank P. ;
Howard, Linda ;
Dowd, Eilis .
PROTEIN SCIENCE, 2012, 21 (06) :904-909
[64]  
Monfoulet LE, 2014, TISSUE ENG PT A, V20, P1827, DOI [10.1089/ten.tea.2013.0500, 10.1089/ten.TEA.2013.0500]
[65]   Human Mesenchymal Stem Cell Failure to Adapt to Glucose Shortage and Rapidly Use Intracellular Energy Reserves Through Glycolysis Explains Poor Cell Survival After Implantation [J].
Moya, Adrien ;
Paquet, Joseph ;
Deschepper, Mickael ;
Larochette, Nathanael ;
Oudina, Karim ;
Denoeud, Cyprien ;
Bensidhoum, Morad ;
Logeart-Avramoglou, Delphine ;
Petite, Herve .
STEM CELLS, 2018, 36 (03) :363-376
[66]   Quiescence Preconditioned Human Multipotent Stromal Cells Adopt a Metabolic Profile Favorable for Enhanced Survival under Ischemia [J].
Moya, Adrien ;
Larochette, Nathanael ;
Paquet, Joseph ;
Deschepper, Mickael ;
Bensidhoum, Morad ;
Izzo, Valentina ;
Kroemer, Guido ;
Petite, Herve ;
Logeart-Avramoglou, Delphine .
STEM CELLS, 2017, 35 (01) :181-196
[67]   Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment [J].
Mylotte, Louise A. ;
Duffy, Angela M. ;
Murphy, Mary ;
O'Brien, Timothy ;
Samali, Afshin ;
Barry, Frank ;
Szegezdi, Eva .
STEM CELLS, 2008, 26 (05) :1325-1336
[68]   Autologous Bone Marrow-Derived Mesenchymal Stem Cells Versus Autologous Chondrocyte Implantation An Observational Cohort Study [J].
Nejadnik, Hossein ;
Hui, James H. ;
Choong, Erica Pei Feng ;
Tai, Bee-Choo ;
Lee, Eng Hin .
AMERICAN JOURNAL OF SPORTS MEDICINE, 2010, 38 (06) :1110-1116
[69]   Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation [J].
Newland, Heike ;
Eigel, Dimitri ;
Rosser, Anne E. ;
Werner, Carsten ;
Newland, Ben .
BIOMATERIALS SCIENCE, 2018, 6 (10) :2571-2577
[70]   Synovial tissue hypoxia and inflammation in vivo [J].
Ng, C. T. ;
Biniecka, M. ;
Kennedy, A. ;
McCormick, J. ;
FitzGerald, O. ;
Bresnihan, B. ;
Buggy, D. ;
Taylor, C. T. ;
O'Sullivan, J. ;
Fearon, U. ;
Veale, D. J. .
ANNALS OF THE RHEUMATIC DISEASES, 2010, 69 (07) :1389-1395
234567891011