Concise review: Understanding and leveraging cell metabolism to enhance mesenchymal stem cell transplantation survival in tissue engineering and regenerative medicine applications

被引：82
作者：
Salazar-Noratto, Giuliana E. [1 ,2 ]
Luo, Guotian [1 ,2 ]
Denoeud, Cyprien [1 ,2 ]
Padrona, Mathilde [1 ,2 ]
Moya, Adrien [3 ,4 ,5 ]
Bensidhoum, Morad [1 ,2 ]
Bizios, Rena [6 ]
Potier, Esther [1 ,2 ]
Logeart-Avramoglou, Delphine [1 ,2 ]
Petite, Herve [1 ,2 ]
机构：
[1] Univ Paris, B3OA, CNRS, INSERM, Paris, France
[2] Ecole Natl Vet Alfort, B3OA, Maisons Alfort, France
[3] South Florida Vet Affairs Fdn Res & Educ Inc, Miami, FL USA
[4] Bruce W Carter VAMC, Educ & Clin Ctr, Geriatr Res, Miami, FL USA
[5] Bruce W Carter VAMC, Res Serv, Miami, FL USA
[6] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA
来源：
STEM CELLS | 2020年 / 38卷 / 01期
关键词：
bioenergetics; cell-based therapies; cell delivery and transplantation; cell survival; mesenchymal stem cells; metabolism; multipotent stromal cells; skeletal stem cells; tissue engineering and regenerative medicine; ENDOPLASMIC-RETICULUM STRESS; MARROW STROMAL CELLS; SHOCK-PROTEIN; 27; BONE-MARROW; IN-VITRO; OSTEOGENIC DIFFERENTIATION; THERAPEUTIC-EFFICACY; OXYGEN-CONSUMPTION; ENERGY-METABOLISM; INFARCTED HEART;
D O I：
10.1002/stem.3079
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
In tissue engineering and regenerative medicine, stem cell-specifically, mesenchymal stromal/stem cells (MSCs)-therapies have fallen short of their initial promise and hype. The observed marginal, to no benefit, success in several applications has been attributed primarily to poor cell survival and engraftment at transplantation sites. MSCs have a metabolism that is flexible enough to enable them to fulfill their various cellular functions and remarkably sensitive to different cellular and environmental cues. At the transplantation sites, MSCs experience hostile environments devoid or, at the very least, severely depleted of oxygen and nutrients. The impact of this particular setting on MSC metabolism ultimately affects their survival and function. In order to develop the next generation of cell-delivery materials and methods, scientists must have a better understanding of the metabolic switches MSCs experience upon transplantation. By designing treatment strategies with cell metabolism in mind, scientists may improve survival and the overall therapeutic potential of MSCs. Here, we provide a comprehensive review of plausible metabolic switches in response to implantation and of the various strategies currently used to leverage MSC metabolism to improve stem cell-based therapeutics. Stem Cells 2019
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页码：22 / 33
页数：12
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