The immune response and aging in chronic inflammatory demyelinating polyradiculoneuropathy

被引：10

作者：

Hagen, Kathleen M. ^{[1
]}

Ousman, Shalina S. ^{[2
]}

机构：

[1] Univ Calgary, Hotchkiss Brain Inst, Dept Neurosci, Calgary, AB T2N 4N1, Canada

[2] Univ Calgary, Hotchkiss Brain Inst, Dept Clin Neurosci & Cell Biol & Anat, Calgary, AB T2N 4N1, Canada

来源：

JOURNAL OF NEUROINFLAMMATION | 2021年 / 18卷 / 01期

基金：

加拿大健康研究院;

关键词：

Peripheral nervous system; Chronic inflammatory demyelinating polyradiculoneuropathy; Immune system; Aging; Immunosenescence; GUILLAIN-BARRE-SYNDROME; REGULATORY T-CELLS; NERVE MYELIN PROTEINS; NECROSIS-FACTOR-ALPHA; PERIPHERAL-NERVE; CEREBROSPINAL-FLUID; NEUROFASCIN-155; IGG4; CLINICAL-FEATURES; ALLERGIC NEURITIS; MEMORY SUBSETS;

D O I：

10.1186/s12974-021-02113-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) consists of various autoimmune subtypes in which the peripheral nervous system (PNS) is attacked. CIDP can follow a relapsing-remitting or progressive course where the resultant demyelination caused by immune cells (e.g., T cells, macrophages) and antibodies can lead to disability in patients. Importantly, the age of CIDP patients has a role in their symptomology and specific variants have been associated with differing ages of onset. Furthermore, older patients have a decreased frequency of functional recovery after CIDP insult. This may be related to perturbations in immune cell populations that could exacerbate the disease with increasing age. In the present review, the immune profile of typical CIDP will be discussed followed by inferences into the potential role of relevant aging immune cell populations. Atypical variants will also be briefly reviewed followed by an examination of the available studies on the immunology underlying them.

引用

页数：18

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