PARKINSON'S DISEASE Mitochondrial damage control

被引：41
作者：
Abeliovich, Asa [1 ,2 ,3 ,4 ]
机构：
[1] Columbia Univ, Taub Inst Aging Brain, New York, NY 10032 USA
[2] Columbia Univ, Dept Cell Biol, New York, NY 10032 USA
[3] Columbia Univ, Dept Pathol, New York, NY 10032 USA
[4] Columbia Univ, Dept Neurol, New York, NY 10032 USA
来源：
NATURE | 2010年 / 463卷 / 7282期
关键词：
DROSOPHILA-PINK1;
D O I：
10.1038/463744a
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Defects in mitochondria are implicated in Parkinson's disease. Study of a quality-control pathway involving the proteins PINK1 and Parkin provides further clues about the mechanism involved.
引用
收藏
页码：744 / 745
页数：2
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共 15 条
  • [1] Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    Clark, Ira E.
    Dodson, Mark W.
    Jiang, Changan
    Cao, Joseph H.
    Huh, Jun R.
    Seol, Jae Hong
    Yoo, Soon Ji
    Hay, Bruce A.
    Guo, Ming
    [J]. NATURE, 2006, 441 (7097) : 1162 - 1166
  • [2] Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
    Gautier, Clement A.
    Kitada, Tohru
    Shen, Jie
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (32) : 11364 - 11369
  • [3] PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
    Geisler, Sven
    Holmstroem, Kira M.
    Skujat, Diana
    Fiesel, Fabienne C.
    Rothfuss, Oliver C.
    Kahle, Philipp J.
    Springer, Wolfdieter
    [J]. NATURE CELL BIOLOGY, 2010, 12 (02) : 119 - U70
  • [4] Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis
    Henchcliffe, Claire
    Beal, M. Flint
    [J]. NATURE CLINICAL PRACTICE NEUROLOGY, 2008, 4 (11): : 600 - 609
  • [5] Parkinson's disease
    Lees, Andrew J.
    Hardy, John
    Revesz, Tamas
    [J]. LANCET, 2009, 373 (9680) : 2055 - 2066
  • [6] Autophagy fights disease through cellular self-digestion
    Mizushima, Noboru
    Levine, Beth
    Cuervo, Ana Maria
    Klionsky, Danial J.
    [J]. NATURE, 2008, 451 (7182) : 1069 - 1075
  • [7] Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    Narendra, Derek
    Tanaka, Atsushi
    Suen, Der-Fen
    Youle, Richard J.
    [J]. JOURNAL OF CELL BIOLOGY, 2008, 183 (05) : 795 - 803
  • [8] PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
    Narendra, Derek P.
    Jin, Seok Min
    Tanaka, Atsushi
    Suen, Der-Fen
    Gautier, Clement A.
    Shen, Jie
    Cookson, Mark R.
    Youle, Richard J.
    [J]. PLOS BIOLOGY, 2010, 8 (01)
  • [9] Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
    Park, Jeehye
    Lee, Sung Bae
    Lee, Sungkyu
    Kim, Yongsung
    Song, Saera
    Kim, Sunhong
    Bae, Eunkyung
    Kim, Jaeseob
    Shong, Minho
    Kim, Jin-Man
    Chung, Jongkyeong
    [J]. NATURE, 2006, 441 (7097) : 1157 - 1161
  • [10] The PINK1/Parkin pathway regulates mitochondrial morphology
    Poole, Angela C.
    Thomas, Ruth E.
    Andrews, Laurie A.
    McBride, Heidi M.
    Whitworth, Alexander J.
    Pallanck, Leo J.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (05) : 1638 - 1643
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