Bimodal control of stimulated food intake by the endocannabinoid system

被引：231

作者：

Bellocchio, Luigi ^{[1
,2
]}

Lafenetre, Pauline ^{[1
,2
]}

Cannich, Astrid ^{[1
,2
]}

Cota, Daniela ^{[2
,3
]}

Puente, Nagore ^{[4
]}

Grandes, Pedro

Chaouloff, Francis ^{[1
,2
]}

Piazza, Pier Vincenzo ^{[2
,5
]}

Marsicano, Giovanni ^{[1
,2
]}

机构：

[1] INSERM, U862, NeuroCtr Magendie Endocannabinoids & Neuroadaptat, Bordeaux, France

[2] Univ Bordeaux, Bordeaux, France

[3] INSERM, U862, NeuroCtr Magendie Energy Balance & Obes, Bordeaux, France

[4] Univ Basque Country, Dept Neurosci, Fac Med & Dent, Leioia, Spain

[5] INSERM, U862, NeuroCtr Magendie, Bordeaux, France

来源：

NATURE NEUROSCIENCE | 2010年 / 13卷 / 03期

关键词：

ENERGY; INTEGRATION; NEURONS;

D O I：

10.1038/nn.2494

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Activation of cannabinoid type-1 receptors (CB1) is universally recognized as a powerful endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not fully understood. Using combined genetic and pharmacological approaches in mice, we found that ventral striatal CB1 receptors exerted a hypophagic action through inhibition of GABAergic transmission. Conversely, brain CB1 receptors modulating excitatory transmission mediated the well-known orexigenic effects of cannabinoids.

引用

收藏

页码：281 / 283

页数：3

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