Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 invitro

被引：36
作者：
Patin, Emmanuel C. [1 ,2 ,3 ,6 ]
Willcocks, Sam [1 ]
Orr, Selinda [3 ]
Ward, Theresa H. [1 ]
Lang, Roland [4 ]
Schaible, Ulrich E. [1 ,2 ,5 ]
机构：
[1] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Immunol & Infect, London WC1, England
[2] Res Ctr Borstel, Prior Area Infect, Pk Allee 1-40, D-23845 Borstel, Germany
[3] Cardiff Univ, Sch Med, Inst Infect & Immun, Cardiff CF10 3AX, S Glam, Wales
[4] Univ Erlangen Nurnberg, Univ Hosp Erlangen, Inst Clin Microbiol Immunol & Hyg, D-91054 Erlangen, Germany
[5] TTU TB, German Ctr Infect Res, Borstel, Germany
[6] Inst Pasteur, Unite INSERM U1019, F-59019 Lille, France
来源：
INNATE IMMUNITY | 2016年 / 22卷 / 03期
基金：
英国惠康基金;
关键词：
Mycobacteria; Mincle; IL-10; macrophage; receptor; PROTECTION; RECEPTORS; CYTOKINES;
D O I：
10.1177/1753425916636671
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.
引用
收藏
页码：181 / 185
页数：5
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