Famciclovir: a focus on efficacy and safety

被引:16
作者
Mubareka, Samira [1 ,2 ]
Leung, Victor [3 ]
Aoki, Fred Y. [4 ]
Vinh, Donald C. [3 ]
机构
[1] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Microbiol, Dept Lab Med & Pathobiol,Fac Med, Toronto, ON M4N 3M5, Canada
[2] Univ Toronto, Dept Med, Res Inst, Div Infect Dis, Toronto, ON M4N 3M5, Canada
[3] McGill Univ, Ctr Hlth, Div Infect Dis, Dept Med Microbiol,Dept Med, Montreal, PQ H3G 1A4, Canada
[4] Univ Manitoba, Dept Internal Med, Infect Dis Sect, Dept Pharmacol & Therapeut,Dept Med Microbiol, Winnipeg, MB R3E 0W3, Canada
关键词
antivirals; famciclovir; guanosine analogue; hepatitis B virus; herpes simplex virus; penciclovir; protease inhibitor; varicella zoster virus; HERPES-SIMPLEX-VIRUS; RECURRENT GENITAL HERPES; PLACEBO-CONTROLLED TRIAL; CHRONIC HEPATITIS-B; VARICELLA-ZOSTER-VIRUS; PATIENT-INITIATED FAMCICLOVIR; NUCLEOSIDE ANALOG PENCICLOVIR; ACYCLOVIR-CONTROLLED TRIAL; DAILY ORAL FAMCICLOVIR; BLIND CLINICAL-TRIAL;
D O I
10.1517/14740338.2010.485189
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Importance of the field: Famciclovir is the prodrug of penciclovir, a guanosine analogue that inhibits viruses of the a sub-family of the Herpesviridae, as well as hepatitis B virus. It is indicated for management of mucocutaneous herpes simplex virus disease and acute herpes zoster, and has been investigated for management of hepatitis B virus infection. Areas covered in this review: Data for this review were identified by searches of papers published in English on Medline and Scopus, spanning the years 1975 through 1 February 2010 with the key words: 'famciclovir', 'famvir', 'penciclovir', 'herpes', 'oral', 'genital', 'varicella', 'zoster' and 'virus' in association with 'safety', 'toxicity', 'tolerability', 'efficacy' and 'indications'. Relevant references were also obtained from articles acquired through the search strategy. What the reader will gain: Readers are also provided with up-to-date information on the use of famciclovir for infections due to herpes simplex, varicella zoster and hepatitis B viruses. Clinical data pertaining to the safety and tolerability of famciclovir are also reviewed. Take home message: Famciclovir is a safe, convenient, and well-tolerated drug when used for its approved indications. The most common side effects indicated in the majority of studies were headache and nausea. Data for its use in childhood and pregnancy are limited.
引用
收藏
页码:643 / 658
页数:16
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