The clearance of apoptotic cells by complement

被引：42
作者：
Flierman, Roelof [1 ]
Daha, Mohamed R. [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Nephrol, Leiden, Netherlands
来源：
IMMUNOBIOLOGY | 2007年 / 212卷 / 4-5期
关键词：
apoptosis; complement; systemic lupus erythematosus;
D O I：
10.1016/j.imbio.2006.11.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The complement system is implicated among others in the clearance of apoptotic cells, and deficiency for different components of the complement system is associated with aberrant handling of apoptotic material. As a result of this, it is thought that the complement system is involved in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE) which affects multiple organs. In this review, the authors highlight the available data on complement and apoptosis, as well as the role of complement in severe autoimmune diseases like SLE. (c) 2006 Elsevier GmbH. All rights reserved.
引用
收藏
页码：363 / 370
页数：8
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