Arrest of CFTRΔF508 folding

被引：21
|
作者：
Cyr, DM [1 ]
机构：
[1] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, N Carolina Cyst Fibrosis Res Ctr, Chapel Hill, NC 27599 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2005年 / 12卷 / 01期
关键词：
D O I：
10.1038/nsmb0105-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The deletion of residue 508 in CFTR is the most common cystic fibrosis-causing mutation. Recent studies indicate that the main chain and side chain of this residue contribute to the proper folding of CFTR at different stages.
引用
收藏
页码：2 / 3
页数：2
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