Development of an Ointment Formulation Using Hot-Melt Extrusion Technology

被引：49

作者：

Bhagurkar, Ajinkya M. ^{[1
]}

Angamuthu, Muralikrishnan ^{[1
]}

Patil, Hemlata ^{[1
]}

Tiwari, Roshan V. ^{[1
]}

Maurya, Abhijeet ^{[1
]}

Hashemnejad, Seyed Meysam ^{[2
]}

Kundu, Santanu ^{[2
]}

Murthy, S. Narasimha ^{[1
]}

Repka, Michael A. ^{[1
,3
]}

机构：

[1] Univ Mississippi, Sch Pharm, Dept Pharmaceut & Drug Delivery, University, MS 38677 USA

[2] Mississippi State Univ, Dave C Swalm Sch Chem Engn, Oktibbeha Cty, MS 39762 USA

[3] Univ Mississippi, Sch Pharm, Pii Ctr Pharmaceut Technol, University, MS 38677 USA

来源：

AAPS PHARMSCITECH | 2016年 / 17卷 / 01期

关键词：

hot-melt extrusion; lidocaine; ointment; PEG; texture analyzer; SOLID LIPID NANOPARTICLES; IN-VITRO RELEASE; ACYCLOVIR;

D O I：

10.1208/s12249-015-0453-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ointments are generally prepared either by fusion or by levigation methods. The current study proposes the use of hot-melt extrusion (HME) processing for the preparation of a polyethylene glycol base ointment. Lidocaine was used as a model drug. A modified screw design was used in this process, and parameters such as feeding rate, barrel temperature, and screw speed were optimized to obtain a uniform product. The product characteristics were compared with an ointment of similar composition prepared by conventional fusion method. The rheological properties, drug release profile, and texture characteristics of the hot-melt extruded product were similar to the conventionally prepared product. This study demonstrates a novel application of the hot-melt extrusion process in the manufacturing of topical semi-solids.

引用

页码：158 / 166

页数：9

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