Basophils as Th2-inducing antigen-presenting cells

被引：17

作者：

Yoshimoto, Tomohiro ^{[1
]}

机构：

[1] Hyogo Coll Med, Lab Allerg Dis, Inst Adv Med Sci, Nishinomiya, Hyogo 6638501, Japan

来源：

INTERNATIONAL IMMUNOLOGY | 2010年 / 22卷 / 07期

基金：

日本学术振兴会;

关键词：

allergy; antigen presentation; dendritic cells; IgE; L-4; T-CELLS; MAST-CELLS; ALLERGIC INFLAMMATION; IL-4; PRODUCTION; IN-VIVO; CYTOKINE; RECEPTOR; DIFFERENTIATION; INTERLEUKIN-18; EXPRESSION;

D O I：

10.1093/intimm/dxq052

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies have revealed a role for basophils as antigen-presenting cells that preferentially induce T(h)2 cells in response to complexes of antigen plus antigen-specific IgE, to protease allergens or to helminthic parasites in vitro and in vivo through the production of 'early IL-4' and the presentation to CD4(+) T cells of complexes of peptide plus MHC class II. These findings have revealed previously unknown functions of basophils and will potentially aid the design of novel therapeutic strategies for T(h)2-IgE-mediated diseases such as bronchial asthma.

引用

页码：543 / 550

页数：8

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