(-)- and (+)-Asperginulin A, a Pair of Indole Diketopiperazine Alkaloid Dimers with a 6/5/4/5/6 Pentacyclic Skeleton from the Mangrove Endophytic Fungus Aspergillus sp. SK-28

被引：45

作者：

Cai, Runlin ^{[1
]}

Jiang, Hongming ^{[1
]}

Xiao, Zeen ^{[1
]}

Cao, Wenhao ^{[2
]}

Yang, Tao ^{[2
]}

Liu, Zhaoming ^{[1
]}

Lin, Shao'e ^{[1
]}

Long, Yuhua ^{[3
]}

She, Zhigang ^{[1
,4
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Guangdong, Peoples R China

[2] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China

[3] South China Normal Univ, Sch Chem, Guangzhou 510006, Guangdong, Peoples R China

[4] Southern Marine Sci & Engn Guangdong Lab, Zhuhai 519082, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 23期

基金：

中国国家自然科学基金;

关键词：

A-C; SESTERTERPENOIDS; SPONGE;

D O I：

10.1021/acs.orglett.9b03796

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A pair of enantiomeric indole diketopiperazine alkaloid dimers [(-)- and (+)-asperginulin A (1a and 1b)] with an unprecedented 6/5/4/5/6 pentacyclic skeleton were isolated from the mangrove endophytic fungus Aspergillus sp. SK-28. The enantiomeric dimers were separated by chiral-phase HPLC. Their structures including absolute configurations were elucidated by spectroscopic analysis, X-ray diffraction, and quantum chemical calculation. (+)-Asperginulin A (1b) exhibited antifouling activity against the barnacle Balanus reticulatus.

引用

页码：9633 / 9636

页数：4

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