Sensitive spectrophotometric determination of some dibenzazepine drugs with diazotized P-phenylenediamine dihydrochloride

被引：10

作者：

Nagaraja, P ^{[1
]}

Silwadi, MF ^{[1
]}

Syed, AA ^{[1
]}

机构：

[1] Univ Mysore, Dept Chem, Mysore 570006, Karnataka, India

来源：

ANALYTICAL LETTERS | 2000年 / 33卷 / 14期

关键词：

tricyclic drugs; dibenzazepines; P-phenylenediamine; spectrophotometry; diazotization;

D O I：

10.1080/00032710008543230

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple, sensitive and selective spectrophotometric procedure was developed for the determination of imipramine hydrochloride, desipramine hydrochloride, clomipramine hydrochloride and trimipramine maleate belonging to dibenzazepine class of drugs. The method is based on the interaction of diazotized p-phenylenediamine dihydrochloride with the drug in sulphuric acid medium. The resulting chromophore was measured at 565 nm, and was stable for about 2.5 hr. The commonly encountered excipients and additives do not interfere with the determination. Dibenzazepine drugs can be determined in the range of 0.1-4.0 mug/ml, with a relative standard deviation of 1.92% for ten replicate measurement of 2.0 mug/ml dibenzazepine drugs. Results from the analysis of preformulations and commercial tablets by this procedure agree well with those of the official method.

引用

页码：2913 / 2926

页数：14

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