Effects of aging on the male reproductive system

被引：183

作者：

Gunes, Sezgin ^{[1
,2
]}

Hekim, Gulgez Neslihan Taskurt ^{[1
]}

Arslan, Mehmet Alper ^{[1
,2
]}

Asci, Ramazan ^{[2
,3
]}

机构：

[1] Ondokuz Mayis Univ, Dept Med Biol, Fac Med, TR-55139 Samsun, Turkey

[2] Ondokuz Mayis Univ, Hlth Sci Inst, Dept Multidisciplinary Mol Med, TR-55139 Samsun, Turkey

[3] Ondokuz Mayis Univ, Fac Med, Dept Urol, TR-55139 Samsun, Turkey

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 2016年 / 33卷 / 04期

关键词：

Aging; Gonads; Hormone; Oxidative stress; Telomeres; SELFISH SPERMATOGONIAL SELECTION; FOLLICLE-STIMULATING-HORMONE; PITUITARY-GONADAL AXIS; DE-NOVO MUTATIONS; MIDDLE-AGED MEN; PATERNAL AGE; OXIDATIVE STRESS; REACTIVE OXYGEN; SEMEN QUALITY; DNA-DAMAGE;

D O I：

10.1007/s10815-016-0663-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The study aims to discuss the effects of aging on the male reproductive system. A systematic review was performed using PubMed from 1980 to 2014. Aging is a natural process comprising of irreversible changes due to a myriad of endogenous and environmental factors at the level of all organs and systems. In modern life, as more couples choose to postpone having a child due to various socioeconomic reasons, research for understanding the effects of aging on the reproductive system has gained an increased importance. Paternal aging also causes genetic and epigenetic changes in spermatozoa, which impair male reproductive functions through their adverse effects on sperm quality and count as, well as, on sexual organs and the hypothalamic-pituitary-gonadal axis. Hormone production, spermatogenesis, and testes undergo changes as a man ages. These small changes lead to decrease in both the quality and quantity of spermatozoa. The offspring of older fathers show high prevalence of genetic abnormalities, childhood cancers, and several neuropsychiatric disorders. In addition, the latest advances in assisted reproductive techniques give older men a chance to have a child even with poor semen parameters. Further studies should investigate the onset of gonadal senesce and its effects on aging men.

引用

页码：441 / 454

页数：14

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