Effect of Lactobacillus Strains on Intestinal Microflora and Mucosa Immunity in Escherichia coli O157:H7-Induced Diarrhea in Mice

被引：31

作者：

Bian, Xin ^{[1
]}

Wang, Ting-ting ^{[1
]}

Xu, Min ^{[1
]}

Evivie, Smith Etareri ^{[1
]}

Luo, Guang-Wen ^{[1
]}

Liang, Hong-zhang ^{[1
]}

Yu, Shang-fu ^{[1
]}

Huo, Gui-Cheng ^{[1
]}

机构：

[1] Northeast Agr Univ, Coll Food Sci, Key Lab Dairy Sci, Harbin 150030, Heilongjiang, Peoples R China

来源：

CURRENT MICROBIOLOGY | 2016年 / 73卷 / 01期

关键词：

LACTIC-ACID BACTERIA; PROFILES; GUT;

D O I：

10.1007/s00284-016-1010-3

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study investigated the effects of KLDS 1.8701 and AD1 administrations by gavage on intestinal microflora and mucosal immunity in diarrhea mice infected by Escherichia coli O157:H7 compared to normal mice. The levels of E. coli, Enterobacteria, and Enterococcus decreased significantly (P < 0.05), while viable counts of Lactobacilli and Bifidobacterium increased in diarrhea mice. Moreover, KLDS 1.8701 and AD1 improved secretion of secretory immunoglobulin A and enhanced the levels of interferon-gamma and interleukin. Results indicate that KLDS 1.8701 and AD1 could effectively alleviate diarrhea in mice via modulation of intestinal microflora and improve the function of immune system. The study on the effect of KLDS1.8701 and AD1 supplementation in human flora-associated animal models was recommended.

引用

页码：65 / 70

页数：6

共 23 条

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