Human endothelial dysfunction: EDRFs

被引：80
作者：
Flammer, Andreas J. [3 ]
Luescher, Thomas F. [1 ,2 ,3 ]
机构：
[1] Univ Zurich Hosp, CH-8091 Zurich, Switzerland
[2] Univ Zurich Irchel, Inst Physiol, CH-8057 Zurich, Switzerland
[3] Cardiol Univ Hosp Zurich, Ctr Cardiovasc, Zurich, Switzerland
来源：
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2010年 / 459卷 / 06期
基金：
瑞士国家科学基金会;
关键词：
Endothelium; Endothelium-derived relaxing factor (EDRF); Nitric oxide; Prostacyclin; Endothelium-derived hyperpolarizing factor; DEPENDENT VASCULAR RELAXATION; GAP JUNCTIONAL COMMUNICATION; FLOW-MEDIATED VASODILATION; NITRIC-OXIDE AVAILABILITY; SMOOTH-MUSCLE; CARDIOVASCULAR EVENTS; CORONARY-ARTERIES; RELAXING FACTOR; CIGARETTE-SMOKING; PROGNOSTIC VALUE;
D O I：
10.1007/s00424-010-0822-4
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Since the detection of nitric oxide two and a half decades ago, there has been an incredible boost in endothelial function research, which is fascinating the research community. Physiologically, endothelial cells synthesize a number of vasoactive substances. In particular, several endothelium-derived relaxing factors (EDRFs) have been characterized, whereby nitric oxide is the most important. In humans, endothelial dysfunction is one of the first clinically detectable alterations in the development of atherosclerosis and is characterized by an imbalance in the release of vasoactive substances. Thus, it is the aim of this article to give an overview about endothelial function in humans, to summarize the different possibilities to assess endothelial function in this species, and to give an overview of the role of EDRFs in different cardiovascular diseases.
引用
收藏
页码：1005 / 1013
页数：9
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