Clofazimine as a Treatment for Multidrug-Resistant Tuberculosis: A Review

被引：15

作者：

Nugraha, Rhea Veda ^{[1
]}

Yunivita, Vycke ^{[2
]}

Santoso, Prayudi ^{[3
]}

Aarnoutse, Rob E. ^{[4
]}

Ruslami, Rovina ^{[2
]}

机构：

[1] Univ Padjadjaran, Fac Med, Dept Biomed Sci, Bandung 40161, Indonesia

[2] Univ Padjadjaran, Fac Med, Dept Biomed Sci, Div Pharmacol & Therapy, Bandung 40161, Indonesia

[3] Univ Padjadjaran, Hasan Sadikin Hosp, Fac Med, Dept Internal Med, Bandung 40161, Indonesia

[4] Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Dept Pharm, NL-6255HB Nijmegen, Netherlands

来源：

SCIENTIA PHARMACEUTICA | 2021年 / 89卷 / 02期

关键词：

clofazimine; MDR-TB; efficacy; safety; tolerability; MYCOBACTERIUM-TUBERCULOSIS; MOUSE MODEL; ANTIMICROBIAL ACTIVITY; CROSS-RESISTANCE; IN-VITRO; MDR-TB; DRUG; BEDAQUILINE; OUTCOMES; REGIMEN;

D O I：

10.3390/scipharm89020019

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Multidrug-resistant tuberculosis (MDR-TB) is an infectious disease caused by Mycobacterium tuberculosis which is resistant to at least isoniazid and rifampicin. This disease is a worldwide threat and complicates the control of tuberculosis (TB). Long treatment duration, a combination of several drugs, and the adverse effects of these drugs are the factors that play a role in the poor outcomes of MDR-TB patients. There have been many studies with repurposed drugs to improve MDR-TB outcomes, including clofazimine. Clofazimine recently moved from group 5 to group B of drugs that are used to treat MDR-TB. This drug belongs to the riminophenazine class, which has lipophilic characteristics and was previously discovered to treat TB and approved for leprosy. This review discusses the role of clofazimine as a treatment component in patients with MDR-TB, and the drug's properties. In addition, we discuss the efficacy, safety, and tolerability of clofazimine for treating MDR-TB. This study concludes that the clofazimine-containing regimen has better efficacy compared with the standard one and is also well-tolerated. Clofazimine has the potential to shorten the duration of MDR-TB treatment.

引用

页数：18

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