Cytotoxicity of New Ferulic-Acid Derivatives on Human Colon Carcinoma (HCT116) Cells

被引：2

作者：

Bakholdina, L. A. ^{[1
,2
]}

Markova, A. A. ^{[3
]}

Khlebnikov, A., I ^{[4
]}

Sevodin, V. P. ^{[1
]}

机构：

[1] II Polzunov Altai State Tech Univ, Biisk Technol Inst Filial, 27 Trofimov St, Biisk 659305, Altai Krai, Russia

[2] Russian Acad Sci, Inst Problems Chem & Energet Technol, Siberian Branch, Biisk 659322, Altai Krai, Russia

[3] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Moscow 119991, Russia

[4] Natl Res Tomsk Polytech Univ, Tomsk 634050, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2019年 / 53卷 / 06期

关键词：

feruloyl oligosaccharides; synthesis; ferulic-acid esters; cytotoxicity; HCT116 human colon carcinoma; ESTER; RICE;

D O I：

10.1007/s11094-019-02030-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of esters of ferulic acid and alcohols were synthesized and characterized structurally. All tested synthetic compounds were more cytotoxic against HCT116 cell line (human colon carcinoma) than ferulic acid. Benzyl and phenylethyl esters of ferulic acid were the most active compounds (IC50 = 0.0077 and 0.0065 g/L, respectively). Feruloylated wheat-bran oligosaccharides were less active than free ferulic acid against HCT116 tumor cells.

引用

页码：516 / 520

页数：5

共 19 条

[1] Mild reaction of primary alcohols with ferulic acid [J].

Bakholdina, L. A. ;

Khlebnikov, A. I. ;

Sevodin, V. P. .

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 52 (03) :441-443

[2]

Bakholdina LA, 2015, TEKH TEKHNOL PISHCH, V1, P82

[3] SYNTHESIS OF CONIFERYL-C-14 ALCOHOL (4-HYDROXY-3-METHOXYCINNAMYL ALCOHOL) [J].

BALBA, HM ;

STILL, GG .

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1978, 15 :309-319

[4]

Berridge MV, 2005, BIOTECHNOL ANN REV, V11, P127, DOI 10.1016/S1387-2656(05)11004-7

[5]

Bunzel M, 2001, THESIS

[6] Redox regulation of cellular stress response by ferulic acid ethyl ester in human dermal fibroblasts: role of vitagenes [J].

Calabrese, Vittorio ;

Calafato, Stella ;

Puleo, Eduardo ;

Cornelius, Carolin ;

Sapienza, Maria ;

Morganti, Pierfrancesco ;

Mancuso, Cesare .

CLINICS IN DERMATOLOGY, 2008, 26 (04) :358-363

[7] Synthesized esters of ferulic acid induce release of cytochrome c from rat testes mitochondria [J].

Cione, E. ;

Tucci, P. ;

Senatore, V. ;

Perri, M. ;

Trombino, S. ;

Iemma, F. ;

Picci, N. ;

Genchi, G. .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 2008, 40 (01) :19-26

[8] Characterization by LC-MSn of four new classes of chlorogenic acids in green coffee beans:: Dimethoxycinnamoylquinic acids, diferuloylquinic acids, caffeoyl-dimethoxycinnamoylquinic acids, and feruloyl-dimethoxycinnamoylquinic acids [J].

Clifford, MN ;

Knight, S ;

Surucu, B ;

Kuhnert, N .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (06) :1957-1969

[9] Antioxidant properties of feruloyl glycerol derivatives [J].

Compton, David L. ;

Laszlo, Joseph A. ;

Evans, Kervin O. .

INDUSTRIAL CROPS AND PRODUCTS, 2012, 36 (01) :217-221

[10] Preparation of a (±)-1,6-di-O-feruloyl-myo-inositol derivative:: An efficient method for introduction of ferulic acid to 1,6-vicinal hydroxyl groups of myo-inositol [J].

Hosoda, A ;

Nomura, E ;

Mizuno, K ;

Taniguchi, H .

JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (21) :7199-7201

← 1 2 →