Two-Step Senescence-Focused Cancer Therapies

被引：165
作者：
Sieben, Cynthia J. [1 ]
Sturmlechner, Ines [2 ,3 ]
van de Sluis, Bart [3 ]
van Deursen, Jan M. [1 ,2 ]
机构：
[1] Mayo Clin, Biochem & Mol Biol, 200 First St SW, Rochester, MN 55905 USA
[2] Mayo Clin, Dept Pediat & Adolescent Med, 200 First St SW, Rochester, MN 55905 USA
[3] Univ Groningen, Univ Med Ctr Groningen, Mol Genet Sect, Dept Pediat, Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands
来源：
TRENDS IN CELL BIOLOGY | 2018年 / 28卷 / 09期
关键词：
ONCOGENE-INDUCED SENESCENCE; RAS-INDUCED SENESCENCE; DNA-DAMAGE RESPONSE; CELLULAR SENESCENCE; SECRETORY PHENOTYPE; OVARIAN-CANCER; IN-VIVO; MELANOCYTE SENESCENCE; STROMAL SENESCENCE; HUMAN FIBROBLASTS;
D O I：
10.1016/j.tcb.2018.04.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Damaged cells at risk of neoplastic transformation can be neutralized by apoptosis or engagement of the senescence program, which induces permanent cell-cycle arrest and a bioactive secretome that is implicated in tumor immunosurveillance. While from an evolutionary perspective senescence is beneficial in that it protects against malignancies, the accumulation of senescent cells in tissues and organs with aging and at sites of various pathologies is largely detrimental. Because induction of senescence in cancer cells is emerging as a therapeutic concept, it will be important to consider these detrimental effects, including tumor-promoting properties that may drive the formation of secondary tumors or cancer relapse. In this review we discuss the complex relationship between senescence and cancer, and highlight important considerations for therapeutics.
引用
收藏
页码：723 / 737
页数：15
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