IFNγ primes macrophages for inflammatory activation by high molecular weight hyaluronan

被引：18
作者：
Wallet, Mark A. [1 ]
Wallet, Shannon M. [2 ]
Guiulfo, Giorgio [1 ]
Sleasman, John W. [3 ]
Goodenow, Maureen M. [1 ]
机构：
[1] Univ Florida, Dept Pathol Immunol & Lab Med, Gainesville, FL 32610 USA
[2] Univ Florida, Dept Periodontol, Gainesville, FL 32610 USA
[3] Univ S Florida, Dept Pediat, Div Rheumatol Allergy & Immunol, Tampa, FL 33620 USA
来源：
CELLULAR IMMUNOLOGY | 2010年 / 262卷 / 02期
关键词：
Rheumatoid arthritis; Inflammation; Hyaluronan; Macrophages; Interferon gamma; Interleukin-10; Interleukin-12; Tumor necrosis factor; c-Jun; RHEUMATOID-ARTHRITIS; DIFFERENTIATION; POPULATIONS; CYTOKINES; BONE;
D O I：
10.1016/j.cellimm.2010.02.013
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The objective was to assess outcomes of IFN gamma-priming upon macrophage activation by the synovial macromolecule high molecular weight hyaluronan [HMW-HA] in the context of rheumatoid arthritis inflammation. Human macrophages primed by IFN gamma and activated by HMW-HA were evaluated for cytokine secretion by ELISA and Milliplex assay and activation profiles by nuclear transcription factor EIA. IFN gamma-primed, HMW-HA-activated macrophages produced elevated levels of TNF and secreted the TH1 cytokine IL-12p70, while IFN gamma suppressed HMW-HA-induced secretion of the regulatory cytokine IL-10 and activation of the transcription factor c-Jun. IFN gamma modulates the HMW-HA-induced cytokine response profile promoting macrophage activation and inflammatory TH1 cytokine secretion. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：84 / 88
页数：5
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