Genetic manipulation of antibiotic-producing Streptomyces

被引：116
作者：
Baltz, RH
机构：
[1] DowElanco, Indianapolis, IN 46268 USA
[2] Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA
来源：
TRENDS IN MICROBIOLOGY | 1998年 / 6卷 / 02期
关键词：
D O I：
10.1016/S0966-842X(97)01161-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The genetic manipulation of Streptomyces species has been facilitated by the development of versatile cloning vectors, robust gene transfer systems and transposable elements. These molecular genetic tools have been used to construct antibiotic-producing strains with improved properties and recombinants for the production of hybrid glycopeptide and macrolide antibiotics, novel anthelminthic agents and novel cytotoxic anthracyclines.
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页码：76 / 83
页数：8
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