FOOD INTAKE AND EATING BEHAVIOR AFTER BARIATRIC SURGERY

被引:134
作者
Al-Najim, Werd
Docherty, Neil G.
le Roux, Carel W.
机构
[1] Univ Coll Dublin, Sch Med & Med Sci, Conway Inst, Diabet Complicat Res Ctr, Dublin, Ireland
[2] Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Gastrosurg Res & Educ, Gothenburg, Sweden
[3] Imperial Coll London, Invest Sci, London, England
基金
爱尔兰科学基金会;
关键词
ROUX-EN-Y; GLUCAGON-LIKE PEPTIDE-1; GASTRIC BYPASS-SURGERY; LAPAROSCOPIC-SLEEVE-GASTRECTOMY; VERTICAL BANDED GASTROPLASTY; CENTRAL-NERVOUS-SYSTEM; CONDITIONED TASTE-AVERSION; DIETARY ENERGY DENSITY; PHASE INSULIN-RELEASE; HUMAN GUT MICROBIOTA;
D O I
10.1152/physrev.00021.2017
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Obesity is an escalating global chronic disease. Bariatric surgery is a very efficacious treatment for obesity and its comorbidities. Alterations to gastrointestinal anatomy during bariatric surgery result in neurological and physiological changes affecting hypothalamic signaling, gut hormones, bile acids, and gut microbiota, which coalesce to exert a profound influence on eating behavior. A thorough understanding of the mechanisms underlying eating behavior is essential in the management of patients after bariatric surgery. Studies investigating candidate mechanisms have expanded dramatically in the last decade. Herein we review the proposed mechanisms governing changes in eating behavior, food intake, and body weight after bariatric surgery. Additive or synergistic effects of both conditioned and unconditioned factors likely account for the complete picture of changes in eating behavior. Considered application of strategies designed to support the underlying principles governing changes in eating behavior holds promise as a means of optimizing responses to surgery and long-term outcomes.
引用
收藏
页码:1113 / 1141
页数:29
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