Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease

被引：152
作者：
Burillo, Jesus [1 ,2 ,3 ]
Marques, Patricia [1 ,3 ]
Jimenez, Beatriz [1 ,2 ,3 ]
Gonzalez-Blanco, Carlos [1 ,3 ]
Benito, Manuel [1 ,2 ,3 ]
Guillen, Carlos [1 ,2 ,3 ]
机构：
[1] Univ Complutense Madrid, Dept Biochem, Madrid 28040, Spain
[2] Ctr Invest Biomed Red CIBER Diabet & Enfermedades, Madrid 28040, Spain
[3] Gen Direct Univ & Invest CCMM, Mech Insulin Resistance MOIR2, Madrid 28040, Spain
来源：
CELLS | 2021年 / 10卷 / 05期
关键词：
insulin resistance; T3DM; mTOR; ER stress; autophagy; inflammation; ENDOPLASMIC-RETICULUM STRESS; ISLET AMYLOID POLYPEPTIDE; PANCREATIC BETA-CELLS; ACTIVATED PROTEIN-KINASE; TUBEROUS SCLEROSIS COMPLEX-2; DIET-INDUCED OBESITY; ER STRESS; SIGNALING PATHWAY; SKELETAL-MUSCLE; MAMMALIAN TARGET;
D O I：
10.3390/cells10051236
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of insulin resistance. The term insulin resistance is very wide and could affect different proteins involved in insulin signaling, as well as other mechanisms. In this review, we have analyzed the main molecular mechanisms that could be involved in the connection between type 2 diabetes and neurodegeneration, in general, and more specifically with the appearance of Alzheimer's disease. We have studied, in more detail, the different processes involved, such as inflammation, endoplasmic reticulum stress, autophagy, and mitochondrial dysfunction.
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页数：42
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