Four New Gallate Derivatives from Wine-Processed Corni Fructus and Their Anti-Inflammatory Activities

被引：10

作者：

Li, Hong-Bin ^{[1
,2
]}

Feng, Qing-Mei ^{[1
,2
]}

Zhang, Ling-Xia ^{[1
,2
]}

Wang, Jing ^{[1
,2
]}

Chi, Jun ^{[1
,2
]}

Chen, Sui-Qing ^{[1
]}

Wang, Zhi-Min ^{[2
,3
]}

Dai, Li-Ping ^{[1
,2
]}

Xu, Er-Ping ^{[1
,2
]}

机构：

[1] Henan Univ Tradit Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China

[2] Henan Univ Chinese Med, Engn Technol Res Ctr Comprehens Dev & Utilizat Au, Zhengzhou 450046, Peoples R China

[3] China Acad Chinese Med Sci, Inst Chinese Mat Med, Natl Engn Lab Qual Control Technol Chinese Herbal, Beijing 100700, Peoples R China

来源：

MOLECULES | 2021年 / 26卷 / 07期

关键词：

wine-processed Corni fructus; gallate derivatives; anti-inflammatory activity;

D O I：

10.3390/molecules26071851

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new gallate derivatives-ornusgallate A, ent-cornusgallate A, cornusgallate B and C (1a, 1b, 2, 3)-were isolated from the wine-processed fruit of Cornus officinalis. Among them, 1a and 1b are new natural compounds with novel skeletons. Their chemical structures were elucidated by comprehensive spectroscopy methods including NMR, IR, HRESIMS, UV, ECD spectra and single-crystal X-ray diffraction analysis. The in vitro anti-inflammatory activities of all compounds were assayed in RAW 264.7 cells by assessing LPS-induced NO production. As the result, all compounds exhibited anti-inflammatory activities at attested concentrations. Among the tested compounds, compound 2 exhibited the strongest anti- inflammatory activity.

引用

页数：10

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