Current Knowledge on Gene-Environment Interactions in Personality Disorders: an Update

被引：9

作者：

Bulbena-Cabre, Andrea ^{[1
,2
,3
]}

Nia, Anahita Bassir ^{[1
]}

Mercedes Perez-Rodriguez, M. ^{[1
,2
,4
]}

机构：

[1] Yale Univ, Sch Med Mt Sinai, Dept Psychiat, 333 Cedar St, New Haven, CT 06510 USA

[2] James J Peters VA Med Ctr, Mental Illness Res Educ & Clin Ctr, Bronx, NY 10468 USA

[3] Univ Autonoma Barcelona, Dept Psychiat & Forens Med, Barcelona, Spain

[4] Ctr Invest Red Salud Mental, CIBERSAM, Madrid, Spain

来源：

CURRENT PSYCHIATRY REPORTS | 2018年 / 20卷 / 09期

关键词：

Personality disorder; Genetic; Epigenetic; Gene environment interaction; Borderline personality disorder; SEROTONIN TRANSPORTER GENE; GLUCOCORTICOID-RECEPTOR GENE; SERIOUS LIFE EVENTS; BORDERLINE PERSONALITY; CHILDHOOD MALTREATMENT; EPIGENETIC REGULATION; ANTISOCIAL-BEHAVIOR; POLYMORPHISM; 5-HTTLPR; PSYCHIATRIC-DISORDERS; PROMOTER METHYLATION;

D O I：

10.1007/s11920-018-0934-7

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

We review the existing literature on gene-environment interactions (GxE) and epigenetic changes primarily in borderline personality disorder (BPD) but also in antisocial, schizotypal, and avoidant personality disorders. Research supports that susceptibility genes to BPD or its underlying traits may be expressed under certain environmental conditions such as physical or childhood sexual abuse. Epigenetic modifications of neurodevelopment- and stress-related genes are suggested to underlie the relationship between early life adversary and borderline personality disorder. Only limited studies have investigated the role of gene-environment interactions and epigenetic changes in the genesis of antisocial, schizotypal, and avoidant personality disorders. Considering the lack of pharmacological treatment for most personality disorders, the emerging evidence on the critical role of GxE and epigenetic changes in the genesis of personality disorders could help develop more biologically oriented therapeutic approaches. Future studies should explore the potential of this new therapeutic dimension.

引用

页数：14

共 125 条

[1] Polygenic Risk Score, Parental Socioeconomic Status, Family History of Psychiatric Disorders, and the Risk for Schizophrenia A Danish Population-Based Study and Meta-analysis [J].

Agerbo, Esben ;

Sullivan, Patrick F. ;

Vilhjalmsson, Bjarni J. ;

Pedersen, Carsten B. ;

Mors, Ole ;

Borglum, Anders D. ;

Hougaard, David M. ;

Hollegaard, Mads V. ;

Meier, Sandra ;

Mattheisen, Manuel ;

Ripke, Stephan ;

Wray, Naomi R. ;

Mortensen, Preben B. .

JAMA PSYCHIATRY, 2015, 72 (07) :635-641

[2] Association of-717A>G Polymorphism in the C-Reactive Protein Gene (CRP) with Schizotypal Personality Traits [J].

Alfimova, M. V. ;

Golimbet, V. E. ;

Lezheiko, T. V. ;

Kondrat'ev, N. V. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2016, 162 (01) :86-88

[3] Genetics of borderline personality disorder: Systematic review and proposal of an integrative model [J].

Amad, Ali ;

Ramoz, Nicolas ;

Thomas, Pierre ;

Jardri, Renaud ;

Gorwood, Philip .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2014, 40 :6-19

[4]

[Anonymous], 2017, NEUROSCI BIOBEHAV RE

[5] Early traumatic life events, parental attitudes, family history, and birth risk factors in patients with borderline personality disorder and healthy controls [J].

Bandelow, B ;

Krause, J ;

Wedekind, D ;

Broocks, A ;

Hajak, G ;

Rüther, E .

PSYCHIATRY RESEARCH, 2005, 134 (02) :169-179

[6] The Role of Schizotypy in the Study of the Etiology of Schizophrenia Spectrum Disorders [J].

Barrantes-Vidal, Neus ;

Grant, Phillip ;

Kwapil, Thomas R. .

SCHIZOPHRENIA BULLETIN, 2015, 41 :S408-S416

[7] Childhood maltreatment associated with adult personality disorders: Findings from the collaborative longitudinal personality disorders study [J].

Battle, CL ;

Shea, MT ;

Johnson, DM ;

Yen, S ;

Zlotnick, C ;

Zanarini, MC ;

Sanislow, CA ;

Skodol, AE ;

Gunderson, JG ;

Grilo, CM ;

McGlashan, TH ;

Morey, LC .

JOURNAL OF PERSONALITY DISORDERS, 2004, 18 (02) :193-211

[8] Methylation at 5HTT Mediates the Impact of Child Sex Abuse on Women's Antisocial Behavior: An Examination of the Iowa Adoptee Sample [J].

Beach, Steven R. H. ;

Brody, Gene H. ;

Todorov, Alexandre A. ;

Gunter, Tracy D. ;

Philibert, Robert A. .

PSYCHOSOMATIC MEDICINE, 2011, 73 (01) :83-87

[9] Child Maltreatment Moderates the Association of MAOA With Symptoms of Depression and Antisocial Personality Disorder [J].

Beach, Steven R. H. ;

Brody, Gene H. ;

Gunter, Tracy D. ;

Packer, Hans ;

Wernett, Pamela ;

Philibert, Robert A. .

JOURNAL OF FAMILY PSYCHOLOGY, 2010, 24 (01) :12-20

[10] Genetic risk, parent-child relations, and antisocial phenotypes in a sample of African-American males [J].

Beaver, Kevin M. ;

Sak, Ashley ;

Vaske, Jamie ;

Nilsson, Jessica .

PSYCHIATRY RESEARCH, 2010, 175 (1-2) :160-164

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