Antibody humanization: a case of the 'Emperor's new clothes'?

被引：191
作者：
Clark, M [1 ]
机构：
[1] Univ Cambridge, Dept Pathol, Div Immunol, Cambridge CB2 1QP, England
来源：
IMMUNOLOGY TODAY | 2000年 / 21卷 / 08期
关键词：
D O I：
10.1016/S0167-5699(00)01680-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The antiglobulin response is perceived as a major problem in the clinical development of therapeutic antibodies. Successive technical developments such as chimeric, humanized and, now, fully human antibodies claim to offer improved solutions to this problem. Although there is clear evidence that chimeric antibodies are less immunogenic than murine monoclonal antibodies, little evidence exists to support claims for further improvements as a result of more elaborate humanization protocols.
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页码：397 / 402
页数：6
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