Total syntheses of bupleurynol and its analog

被引：8
|
作者：
Ma, Kai-Qing [1 ]
Miao, Yan-Hong [1 ,4 ]
Gao, Xiao-Xia [1 ]
Chao, Jian-Bin [3 ]
Zhang, Xiang [2 ]
Qin, Xue-Mei [1 ]
机构：
[1] Shanxi Univ, Modern Res Ctr Tradit Chinese Med, Taiyuan 030006, Peoples R China
[2] Univ Louisville, Dept Chem, Louisville, KY 40208 USA
[3] Shanxi Univ, Sci Instrument Ctr, Taiyuan 030006, Peoples R China
[4] Shanxi Univ, Coll Chem & Chem Engn, Taiyuan 030006, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2017年 / 28卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Polyacetylenes; Natural product; Bupleurynol; Total synthesis; Julia-Kocienski olefination; POLYACETYLENES; IVORENOLIDE; CATALYSIS; MACROLIDE;
D O I：
10.1016/j.cclet.2016.11.032
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient route to the natural products bupleurynol and its analog (RB-2), isolated from Bupleuri Radix, was established based on versatile intermediate (15). In this synthetic route, Sonogashira and Cadiot-Chodkiewicz coupling as well as Julia-Kocienski olefination are utilized as key steps. The highly efficient synthetic route provides opportunities to explore the biological behavior of bupleurynol and RB-2. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1035 / 1038
页数：4
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