Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins

被引：73

作者：

Liu, Juan ^{[1
]}

Xu, Yangrong ^{[1
]}

Yang, Jingjing ^{[1
]}

Wang, Wenzhi ^{[1
]}

Zhang, Jianqiang ^{[1
]}

Zhang, Renmei ^{[1
]}

Meng, Qingguo ^{[1
]}

机构：

[1] Yantai Univ, Minist Educ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat, 30 Qingquan RD, Laishan Dist 264005, Yantai, Peoples R China

来源：

JOURNAL OF GINSENG RESEARCH | 2017年 / 41卷 / 03期

基金：

中国国家自然科学基金;

关键词：

biological activity; discovery; metabolism; ocotillol-type saponin; semisynthesis; DOXORUBICIN-INDUCED ACUTE; ACUTE MYOCARDIAL INJURY; TRITERPENOID DERIVATIVES; ANTIBACTERIAL EVALUATION; STRUCTURAL DETERMINATION; EPIMERIC DERIVATIVES; DAMMARANE-SAPONINS; PSEUDOGINSENOSIDE-F-11; GINSENG; LEAVES;

D O I：

10.1016/j.jgr.2017.01.001

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported. The biological activities of ocotillol-type saponins include neuroprotective effect, antimyocardial ischemia, antiinflammatory, antibacterial, and antitumor activities. Owing to their chemical structure, pharmacological actions, and the stereoselective activity on antimyocardial ischemia, ocotillol-type saponins are subjected to extensive consideration. In this review, we sum up the discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins. (C) 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC.

引用

页码：373 / 378

页数：6

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