The regulatory role of DPP4 in atherosclerotic disease

被引：20
作者：
Duan, Lihua [1 ,2 ]
Rao, Xiaoquan [2 ]
Xia, Chang [2 ,3 ]
Rajagopalan, Sanjay [2 ]
Zhong, Jixin [2 ]
机构：
[1] Xiamen Univ, Affiliated Hosp 1, Dept Rheumatol & Clin Immunol, Xiamen 361003, Fujian, Peoples R China
[2] Case Western Reserve Univ, Sch Med, Cardiovasc Res Inst, 2103 Cornell Rd,Wolstein Res Bldg 4525, Cleveland, OH 44106 USA
[3] Wuhan Polytech Univ, Dept Microbiol & Immunol, Wuhan 430023, Hubei, Peoples R China
来源：
CARDIOVASCULAR DIABETOLOGY | 2017年 / 16卷
基金：
中国国家自然科学基金;
关键词：
Dipeptidyl peptidase; Gliptins; Atherosclerosis; Incretin; DPP4; inhibitor; DIPEPTIDYL PEPTIDASE-4 INHIBITORS; CARDIOVASCULAR OUTCOMES; HEART-FAILURE; MYOCARDIAL-INFARCTION; ARTERIAL STIFFNESS; ENDOTHELIAL DYSFUNCTION; CLINICAL-TRIALS; POOLED ANALYSIS; SUB-ANALYSIS; BODY-WEIGHT;
D O I：
10.1186/s12933-017-0558-y
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The increasing prevalence of atherosclerosis has become a worldwide health concern. Although significant progress has been made in the understanding of atherosclerosis pathogenesis, the underlying mechanisms are not fully understood. Recent studies suggest dipeptidyl peptidase-4 (DPP4), a regulator of inflammation and metabolism, may be involved in the development of atherosclerotic diseases. There has been increasing clinical and pre-clinical evidence showing DPP4-incretin axis is involved in cardiovascular disease. Although the cardiovascular outcome of DPP4 inhibition or incretin analogues has been or being evaluated by several large scale clinical trials, the exact role of DPP4 in atherosclerotic diseases is not completely understood. In the current review, we will summarize the recent advances in direct and indirect regulatory role of DPP4 in atherosclerosis.
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