Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

被引：56

作者：

Cohen, Philip ^{[1
]}

机构：

[1] Univ Dundee, Coll Life Sci, Prot Phosphorylat Unit, Sir James Black Ctr,MRC, Dundee DD1 5EH, Scotland

来源：

BIOCHEMICAL JOURNAL | 2010年 / 425卷

基金：

英国医学研究理事会;

关键词：

cell regulation; chemical biology; chemical inhibitor; protein kinase; signal transduction; KINASE INHIBITORS; IN-VIVO; SPECIFICITY; UPDATE;

D O I：

10.1042/BJ20091428

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell-permeable chemical inhibitors have become invaluable reagents for the study of cellular regulation. In the present paper, using protein kinase inhibitors as the example, a set of criteria are described that should be met before any investigation using such compounds should be accepted for publication.

引用

页码：53 / 54

页数：2

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