The Sonogashira reaction in water via an amphiphilic resin-supported palladium-phosphine complex under copper-free conditions

被引：110
作者：
Uozumi, Y [1 ]
Kobayashi, Y [1 ]
机构：
[1] Inst Mol Sci, Okazaki, Aichi 4448585, Japan
来源：
HETEROCYCLES | 2003年 / 59卷 / 01期
关键词：
D O I：
10.3987/COM-02-S21
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Sonogashira reaction of aryl halides with terminal alkynes was catalyzed by an amphiphilic polystyrene-poly(ethylene glycol) (PS-PEG) resin-supported palladium-phosphine complex in water to give the corresponding aryl-substituted alkynes in high yields under copper-free conditions. Reaction of o-iodophenol with terminal alkynes under Sonogashira conditions gave benzofuran derivatives in one step.
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页码：71 / 74
页数：4
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