Advances in Closed-Loop Insulin Delivery Systems in Patients with Type 1 Diabetes

被引：21

作者：

Dadlani, Vikash ^{[1
]}

Pinsker, Jordan E. ^{[2
]}

Dassau, Eyal ^{[2
,3
,4
]}

Kudva, Yogish C. ^{[1
]}

机构：

[1] Mayo Clin, Endocrine Res Unit, 200 First St SW, Rochester, MN 55902 USA

[2] Sansum Diabet Res Inst, 2219 Bath St, Santa Barbara, CA 93105 USA

[3] Harvard Univ, Harvard John A Paulson Sch Engn & Appl Sci, 29 Oxford St, Cambridge, MA 02138 USA

[4] Joslin Diabet Ctr, Boston, MA 02215 USA

来源：

CURRENT DIABETES REPORTS | 2018年 / 18卷 / 10期

关键词：

Artificial pancreas; Closed loop; Glycemic variability; Hypoglycemia; Type; 1; diabetes; HORMONE ARTIFICIAL PANCREAS; MODEL-PREDICTIVE CONTROL; OVERNIGHT GLUCOSE CONTROL; PSYCHOLOGICAL STRESS; PHYSICAL-ACTIVITY; OUTCOME MEASURES; GLYCEMIC CONTROL; BIONIC PANCREAS; PUMP THERAPY; HOME-USE;

D O I：

10.1007/s11892-018-1051-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of Review To provide a current review of closed-loop insulin delivery or artificial pancreas (AP) as therapy for people with type 1 diabetes mellitus (T1D) Recent Findings The Medtronic Minimed 670G AP system has been in use in clinical practice since March 2017. Currently, Medtronic is conducting a large randomized clinical trial to evaluate its efficacy further in T1D. Simultaneously, the NIH has funded four research consortia to accelerate progress to approval of other AP and decision support systems. Several research groups are currently developing next-generation AP systems, with a number of companies moving toward releasing closed-loop systems in the future. AP systems are also being tested in select populations such as hypoglycemia-unaware T1D and pregnant T1D. Summary AP research is rapidly advancing. The clinical range of AP will be expanded in the next decade.

引用

页数：10

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