Cloning, sequencing and structural analysis of 976 base pairs of the promoter sequence for the rat lipoprotein lipase gene.: Comparison with the mouse and human sequences

被引：22

作者：

Bey, L

Etienne, J ^{[1
]}

Tse, C

Brault, D

Noé, L

Raisonnier, A

Arnault, F

Hamilton, MT

Galibert, F

机构：

[1] Fac Med St Antoine Tenon, F-75012 Paris, France

[2] CHU Pitie Salpetriere, F-75013 Paris, France

[3] Univ Texas, Hlth Sci Ctr, Dept Integrat Biol Pharmacol & Physiol, Houston, TX USA

[4] Fac Med, CNRS, UPR 41, F-35043 Rennes, France

来源：

GENE | 1998年 / 209卷 / 1-2期

关键词：

transition; transversion; rat insert; restriction sites; stem loops; potential cis-elements;

D O I：

10.1016/S0378-1119(98)00003-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We cloned and sequenced the -976 bp promoter of the rat lipoprotein lipase LPL gene. The sequence was compared with the mouse and human sequences. The homology between the rat and mouse LPL tucleotide sequences was not quite as strong in the promoter sequence as in the coding sequence. Among the 976 nt promoter there were 118 divergences, i.e. 11.8%, compared to only 5.6% for the LPL coding region. However, within the 200 nt immediately 5' to the transcriptional start site (proximal promoter), the divergence was only 4%. New potential cis-elements (such as (CACCC, GATA, GC and GA boxes, IRS, Krox, MEF 2, E-box, CCArGG and 1/2 VDRE) were identified in the rat, mouse or human LPL gene. (C) 1998 Elsevier Science B.V.

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页码：31 / 38

页数：8

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