Updates on the Genomics of Bladder Cancer and Novel Molecular Taxonomy

被引：26
作者：
Al-Ahmadie, Hikmat [1 ]
Netto, George J. [2 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10065 USA
[2] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA
来源：
ADVANCES IN ANATOMIC PATHOLOGY | 2020年 / 27卷 / 01期
关键词：
urothelial carcinoma; divergent differentiation; variant histology; squamous; small cell; neuroendocrine; plasmacytoid; micropapillary; molecular subtypes; TCGA; INVASIVE MICROPAPILLARY CARCINOMA; DIVERGENT HISTOLOGIC DIFFERENTIATION; PLASMACYTOID UROTHELIAL CARCINOMA; SOMATIC ERCC2 MUTATIONS; LARGE NESTED VARIANT; DNA-DAMAGE RESPONSE; VON BRUNN NESTS; HUMAN-PAPILLOMAVIRUS; PROMOTER MUTATIONS; URINARY-BLADDER;
D O I：
10.1097/PAP.0000000000000252
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Urothelial carcinoma (UC) is the most common malignant neoplasm of the bladder that encompasses a wide spectrum of histopathologic features and various molecular alterations and subtypes, responsible for its significant morphologic and genomic heterogeneity. Morphologically, in addition to classic UC (not otherwise specified), many well documented variant histologies are a common finding in invasive UC, and include squamous, glandular, micropapillary, sarcomatoid, small cell/neuroendocrine, clear cell, lymphoepithelioma-like, and plasmacytoid types, among others. This review provides an update on the recent advances in the molecular characterization and novel molecular taxonomy of UC and variant histologies.
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收藏
页码：36 / 43
页数：8
相关论文
共 81 条
  • [41] Carcinosarcoma and sarcomatoid carcinoma of the bladder: Clinicopathological study of 41 cases
    Lopez-Beltran, A
    Pacelli, A
    Rothenberg, HJ
    Wollan, PC
    Zincke, H
    Blute, ML
    Bostwick, DG
    [J]. JOURNAL OF UROLOGY, 1998, 159 (05) : 1497 - 1503
  • [42] INVASIVE MICROPAPILLARY CARCINOMA OF THE BREAST - A NEW SPECIAL TYPE OF INVASIVE MAMMARY-CARCINOMA
    LUNAMORE, S
    GONZALEZ, B
    ACEDO, C
    RODRIGO, I
    LUNA, C
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 1994, 190 (07) : 668 - 674
  • [43] A validation and extended description of the Lund taxonomy for urothelial carcinoma using the TCGA cohort
    Marzouka, Nour-al-dain
    Eriksson, Pontus
    Rovira, Carlos
    Liedberg, Fredrik
    Sjodahl, Gottfrid
    Hoglund, Mattias
    [J]. SCIENTIFIC REPORTS, 2018, 8
  • [44] Moch H., 2016, WHO CLASSIFICATION T
  • [45] DNA Repair Deficiency and Immunotherapy Response
    Mouw, Kent W.
    D'Andrea, Alan D.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (17) : 1710 - +
  • [46] Pathogenesis of invasive micropapillary carcinoma: role of MUC1 glycoprotein
    Nassar, H
    Pansare, V
    Zhang, HQ
    Che, MX
    Sakr, W
    Ali-Fehmi, R
    Grignon, D
    Sarkar, F
    Cheng, J
    Adsay, V
    [J]. MODERN PATHOLOGY, 2004, 17 (09) : 1045 - 1050
  • [47] Plasmacytoid Urothelial Carcinoma Detailed Analysis of Morphology With Clinicopathologic Correlation in 17 Cases
    Nigwekar, Priya
    Tamboli, Pheroze
    Amin, Mitual B.
    Osunkoya, Adeboye O.
    Ben-Dor, David
    Amin, Mahul B.
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2009, 33 (03) : 417 - 424
  • [48] Targeted sequencing of plasmacytoid urothelial carcinoma reveals frequent TERT promoter mutations
    Palsgrove, Doreen N.
    Taheri, Diana
    Springer, Simeon U.
    Cowan, Morgan
    Guner, Gunes
    Rodriguez, Maria A. Mendoza
    Pena, Maria Del Carmen Rodriguez
    Wang, Yuxuan
    Kinde, Isaac
    Ricardo, Bernardo F. P.
    Cunha, Isabela
    Fujita, Kazutoshi
    Ertoy, Dilek
    Kinzler, Kenneth W.
    Bivalacqua, Trinity J.
    Papadopoulos, Nickolas
    Vogelstein, Bert
    Netto, George J.
    [J]. HUMAN PATHOLOGY, 2019, 85 : 1 - 9
  • [49] Penson A, 2019, JAMA ONCOL
  • [50] Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer
    Robertson, A. Gordon
    Kim, Jaegil
    Al-Ahmadie, Hikmat
    Bellmunt, Joaquim
    Guo, Guangwu
    Cherniack, Andrew D.
    Hinoue, Toshinori
    Laird, Peter W.
    Hoadley, Katherine A.
    Akbani, Rehan
    Castro, Mauro A. A.
    Gibb, Ewan A.
    Kanchi, Rupa S.
    Gordenin, Dmitry A.
    Shukla, Sachet A.
    Sanchez-Vega, Francisco
    Hansel, Donna E.
    Czerniak, Bogdan A.
    Reuter, Victor E.
    Su, Xiaoping
    Carvalho, Benilton de Sa
    Chagas, Vinicius S.
    Mungall, Karen L.
    Sadeghi, Sara
    Pedamallu, Chandra Sekhar
    Lu, Yiling
    Klimczak, Leszek J.
    Zhang, Jiexin
    Choo, Caleb
    Ojesina, Akinyemi I.
    Bullman, Susan
    Leraas, Kristen M.
    Lichtenberg, Tara M.
    Wu, Catherine J.
    Schultz, Nicholaus
    Getz, Gad
    Meyerson, Matthew
    Mills, Gordon B.
    McConkey, David J.
    Weinstein, John N.
    Kwiatkowski, David J.
    Lerner, Seth P.
    [J]. CELL, 2017, 171 (03) : 540 - +
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