Updates on the Genomics of Bladder Cancer and Novel Molecular Taxonomy

被引：26

作者：

Al-Ahmadie, Hikmat ^{[1
]}

Netto, George J. ^{[2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10065 USA

[2] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA

来源：

ADVANCES IN ANATOMIC PATHOLOGY | 2020年 / 27卷 / 01期

关键词：

urothelial carcinoma; divergent differentiation; variant histology; squamous; small cell; neuroendocrine; plasmacytoid; micropapillary; molecular subtypes; TCGA; INVASIVE MICROPAPILLARY CARCINOMA; DIVERGENT HISTOLOGIC DIFFERENTIATION; PLASMACYTOID UROTHELIAL CARCINOMA; SOMATIC ERCC2 MUTATIONS; LARGE NESTED VARIANT; DNA-DAMAGE RESPONSE; VON BRUNN NESTS; HUMAN-PAPILLOMAVIRUS; PROMOTER MUTATIONS; URINARY-BLADDER;

D O I：

10.1097/PAP.0000000000000252

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Urothelial carcinoma (UC) is the most common malignant neoplasm of the bladder that encompasses a wide spectrum of histopathologic features and various molecular alterations and subtypes, responsible for its significant morphologic and genomic heterogeneity. Morphologically, in addition to classic UC (not otherwise specified), many well documented variant histologies are a common finding in invasive UC, and include squamous, glandular, micropapillary, sarcomatoid, small cell/neuroendocrine, clear cell, lymphoepithelioma-like, and plasmacytoid types, among others. This review provides an update on the recent advances in the molecular characterization and novel molecular taxonomy of UC and variant histologies.

引用

页码：36 / 43

页数：8

共 81 条

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