Lipid mediators of inflammation in rheumatoid arthritis and osteoarthritis

被引：67
作者：
Brouwers, Hilde [1 ]
von Hegedus, Joost [1 ]
Toes, Rene [1 ]
Kloppenburg, Margreet [1 ]
Ioan-Facsinay, Andreea [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Rheumatol, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands
来源：
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2015年 / 29卷 / 06期
关键词：
Osteoarthritis; Rheumatoid arthritis; Lipid mediators; Lipids; Inflammation; Oxylipins; POLYUNSATURATED FATTY-ACIDS; HUMAN ARTICULAR CHONDROCYTES; COLLAGEN-INDUCED ARTHRITIS; DIETARY FISH OIL; PROSTAGLANDIN E-2; LEUKOTRIENE B-4; LYSOPHOSPHATIDIC ACID; KNEE OSTEOARTHRITIS; SYNOVIAL-FLUID; POTENTIAL ROLE;
D O I：
10.1016/j.berh.2016.02.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Rheumatoid arthritis (RA) and osteoarthritis (OA) are inflammatory joint diseases, characterized by pain and structural damage. Besides prostaglandins, usually targeted by non-steroidal anti-inflammatory drugs, other lipids, including fatty acids, phospholipids and other bioactive lipid mediators derived from fatty acids could also contribute to RA and OA. In this review, we present evidence for the role of fatty acids and derivatives in RA and OA by summarizing findings related to their presence in serum and synovial fluid, as well as their association with clinical characteristics and effects on RA and OA tissues in vitro. Finally, a more direct evidence for their role in RA and OA derived from intervention studies in humans or mouse models of disease is summarized. Based on the presented data, we present a research agenda, in which some key unresolved questions regarding the role of lipids in RA and OA are formulated. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：741 / 755
页数：15
相关论文
共 116 条
  • [1] RELATIONSHIP BETWEEN LEUKOTRIENE-B4 AND IMMUNOLOGICAL PARAMETERS IN RHEUMATOID SYNOVIAL-FLUIDS
    AHMADZADEH, N
    SHINGU, M
    NOBUNAGA, M
    TAWARA, T
    [J]. INFLAMMATION, 1991, 15 (06) : 497 - 503
  • [2] Palmitate Has Proapoptotic and Proinflammatory Effects on Articular Cartilage and Synergizes With Interleukin-1
    Alvarez-Garcia, Oscar
    Rogers, Nicole H.
    Smith, Roy G.
    Lotz, Martin K.
    [J]. ARTHRITIS & RHEUMATOLOGY, 2014, 66 (07) : 1779 - 1788
  • [3] Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage:: Evidence for signaling via the EP4 receptor
    Attur, Mukundan
    Al-Mussawir, Hayf E.
    Patel, Jyoti
    Kitay, Alison
    Dave, Mandar
    Palmer, Glyn
    Pillinger, Michael H.
    Abramson, Steven B.
    [J]. JOURNAL OF IMMUNOLOGY, 2008, 181 (07) : 5082 - 5088
  • [4] Low-Grade Inflammation in Symptomatic Knee Osteoarthritis Prognostic Value of Inflammatory Plasma Lipids and Peripheral Blood Leukocyte Biomarkers
    Attur, Mukundan
    Krasnokutsky, Svetlana
    Statnikov, Alexander
    Samuels, Jonathan
    Li, Zhiguo
    Friese, Olga
    Le Graverand-Gastineau, Marie-Pierre Hellio
    Rybak, Leon
    Kraus, Virginia B.
    Jordan, Joanne M.
    Aliferis, Constantin F.
    Abramson, Steven B.
    [J]. ARTHRITIS & RHEUMATOLOGY, 2015, 67 (11) : 2905 - 2915
  • [5] Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study
    Baker, K. R.
    Matthan, N. R.
    Lichtenstein, A. H.
    Niu, J.
    Guermazi, A.
    Roemer, F.
    Grainger, A.
    Nevitt, M. C.
    Clancy, M.
    Lewis, C. E.
    Torner, J. C.
    Felson, D. T.
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2012, 20 (05) : 382 - 387
  • [6] Comparative Effectiveness of Pharmacologic Interventions for Knee Osteoarthritis A Systematic Review and Network Meta-analysis
    Bannuru, Raveendhara R.
    Schmid, Christopher H.
    Kent, David M.
    Vaysbrot, Elizaveta E.
    Wong, John B.
    McAlindon, Timothy E.
    [J]. ANNALS OF INTERNAL MEDICINE, 2015, 162 (01) : 46 - U189
  • [7] Collagen Antibody-Induced Arthritis Evokes Persistent Pain With Spinal Glial Involvement and Transient Prostaglandin Dependency
    Bas, Duygu B.
    Su, Jie
    Sandor, Katalin
    Agalave, Nilesh M.
    Lundberg, Johanna
    Codeluppi, Simone
    Baharpoor, Azar
    Nandakumar, Kutty S.
    Holmdahl, Rikard
    Svensson, Camilla I.
    [J]. ARTHRITIS AND RHEUMATISM, 2012, 64 (12): : 3886 - 3896
  • [8] Monounsaturated and Saturated, but Not n-6 Polyunsaturated Fatty Acids Decrease Cartilage Destruction under Inflammatory Conditions: A Preliminary Study
    Bastiaansen-Jenniskens, Y. M.
    Siawash, M.
    van de Lest, C. H. A.
    Verhaar, J. A. N.
    Kloppenburg, M.
    Zuurmond, A. -M.
    Stojanovic-Susulic, V.
    Van Osch, G. J. V. M.
    Clockaerts, S.
    [J]. CARTILAGE, 2013, 4 (04) : 321 - 328
  • [9] Raised levels of F2-isoprostanes and prostaglandin F2α in different rheumatic diseases
    Basu, S
    Whiteman, M
    Mattey, DL
    Halliwell, B
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2001, 60 (06) : 627 - 631
  • [10] Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)
    Berenbaum, F.
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2013, 21 (01) : 16 - 21
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