Raising the 'Good' Oxidants for Immune Protection

被引:28
作者
Dumas, Alexia [1 ]
Knaus, Ulla G. [1 ]
机构
[1] Univ Coll Dublin, Sch Med, Conway Inst, Dublin, Ireland
来源
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
基金
爱尔兰科学基金会;
关键词
reactive oxygen species; NADPH oxidase; microbiota; host defense; immune signaling; redox medicine; lactobacilli; glucose oxidase; CHRONIC GRANULOMATOUS-DISEASE; NEUTROPHIL EXTRACELLULAR TRAPS; COLONY-STIMULATING FACTOR; FORMYL PEPTIDE RECEPTOR; INFLAMMATORY-BOWEL-DISEASE; REDOX-DEPENDENT REGULATION; EPITHELIAL-CELL MIGRATION; ATP-MEDIATED ACTIVATION; NITRIC-OXIDE SYNTHASE; REACTIVE OXYGEN;
D O I
10.3389/fimmu.2021.698042
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Redox medicine is a new therapeutic concept targeting reactive oxygen species (ROS) and secondary reaction products for health benefit. The concomitant function of ROS as intracellular second messengers and extracellular mediators governing physiological redox signaling, and as damaging radicals instigating or perpetuating various pathophysiological conditions will require selective strategies for therapeutic intervention. In addition, the reactivity and quantity of the oxidant species generated, its source and cellular location in a defined disease context need to be considered to achieve the desired outcome. In inflammatory diseases associated with oxidative damage and tissue injury, ROS source specific inhibitors may provide more benefit than generalized removal of ROS. Contemporary approaches in immunity will also include the preservation or even elevation of certain oxygen metabolites to restore or improve ROS driven physiological functions including more effective redox signaling and cell-microenvironment communication, and to induce mucosal barrier integrity, eubiosis and repair processes. Increasing oxidants by host-directed immunomodulation or by exogenous supplementation seems especially promising for improving host defense. Here, we summarize examples of beneficial ROS in immune homeostasis, infection, and acute inflammatory disease, and address emerging therapeutic strategies for ROS augmentation to induce and strengthen protective host immunity.
引用
收藏
页数:19
相关论文
共 280 条
[21]   INNATE IMMUNITY A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion [J].
Birchenough, George M. H. ;
Nystrom, Elisabeth E. L. ;
Johansson, Malin E. V. ;
Hansson, Gunnar C. .
SCIENCE, 2016, 352 (6293) :1535-1542
[22]   Mortality in randomized trials of antioxidant supplements for primary and secondary prevention - Systematic review and meta-analysis [J].
Bjelakovic, Goran ;
Nikolova, Dimitrinka ;
Gluud, Lise Lotte ;
Simonetti, Rosa G. ;
Gluud, Christian .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 297 (08) :842-857
[23]   To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps [J].
Boeltz, Sebastian ;
Amini, Poorya ;
Anders, Hans-Joachim ;
Andrade, Felipe ;
Bilyy, Rostyslav ;
Chatfield, Simon ;
Cichon, Iwona ;
Clancy, Danielle M. ;
Desai, Jyaysi ;
Dumych, Tetiana ;
Dwivedi, Nishant ;
Gordon, Rachael Ann ;
Hahn, Jonas ;
Hidalgo, Andres ;
Hoffmann, Markus H. ;
Kaplan, Mariana J. ;
Knight, Jason S. ;
Kolaczkowska, Elzbieta ;
Kubes, Paul ;
Leppkes, Moritz ;
Manfredi, Angelo A. ;
Martin, Seamus J. ;
Maueroder, Christian ;
Maugeri, Norma ;
Mitroulis, Ioannis ;
Munoz, Luis E. ;
Nakazawa, Daigo ;
Neeli, Indira ;
Nizet, Victor ;
Pieterse, Elmar ;
Radic, Marko Z. ;
Reinwald, Christiane ;
Ritis, Konstantinos ;
Rovere-Querini, Patrizia ;
Santocki, Michal ;
Schauer, Christine ;
Schett, Georg ;
Shlomchik, Mark Jay ;
Simon, Hans-Uwe ;
Skendros, Panagiotis ;
Stojkov, Darko ;
Vandenabeele, Peter ;
Vanden Berghe, Tom ;
van der Vlag, Johan ;
Vitkov, Ljubomir ;
von Koeckritz-Blickwede, Maren ;
Yousefi, Shida ;
Zarbock, Alexander ;
Herrmann, Martin .
CELL DEATH AND DIFFERENTIATION, 2019, 26 (03) :395-408
[24]   ATP-mediated Activation of the NADPH Oxidase DUOX1 Mediates Airway Epithelial Responses to Bacterial Stimuli [J].
Boots, Agnes W. ;
Hristova, Milena ;
Kasahara, David I. ;
Haenen, Guido R. M. M. ;
Bast, Aalt ;
van der Vliet, Albert .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (26) :17858-17867
[25]   Potential role of Noxes in the protection of mucosae: H2O2 as a bacterial repellent [J].
Botteaux, A. ;
Hoste, C. ;
Dumont, J. E. ;
Van Sande, J. ;
Allaoui, A. .
MICROBES AND INFECTION, 2009, 11 (05) :537-544
[26]   Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease [J].
Bourgonje, Arno R. ;
Feelisch, Martin ;
Faber, Klaas Nico ;
Pasch, Andreas ;
Dijkstra, Gerard ;
van Goor, Harry .
TRENDS IN MOLECULAR MEDICINE, 2020, 26 (11) :1034-1046
[27]   Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens [J].
Branzk, Nora ;
Lubojemska, Aleksandra ;
Hardison, Sarah E. ;
Wang, Qian ;
Gutierrez, Maximiliano G. ;
Brown, Gordon D. ;
Papayannopoulos, Venizelos .
NATURE IMMUNOLOGY, 2014, 15 (11) :1017-1025
[28]   ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease [J].
Brown, Kelly L. ;
Bylund, Johan ;
MacDonald, Kelly L. ;
Song-Zhao, George X. ;
Elliott, Melissa R. ;
Falsafi, Reza ;
Hancock, Robert E. W. ;
Speert, David P. .
CLINICAL IMMUNOLOGY, 2008, 129 (01) :90-102
[29]   Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NF-κB [J].
Bylund, Johan ;
MacDonald, Kelly L. ;
Brown, Kelly L. ;
Mydel, Piotr ;
Collins, L. Vincent ;
Hancock, Robert E. W. ;
Speert, David P. .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (04) :1087-1096
[30]   Altered Humoral Immune Responses and IgG Subtypes in NOX2-Deficient Mice and Patients: A Key Role for NOX2 in Antigen-Presenting Cells [J].
Cachat, Julien ;
Deffert, Christine ;
Alessandrini, Marco ;
Roux-Lombard, Pascale ;
Le Gouellec, Audrey ;
Stasia, Marie-Jose ;
Hugues, Stephanie ;
Krause, Karl-Heinz .
FRONTIERS IN IMMUNOLOGY, 2018, 9