Animals are key to human toxoplasmosis

被引：105

作者：

Schlueter, Dirk ^{[1
,2
]}

Daeubener, Walter ^{[3
]}

Schares, Gereon ^{[4
]}

Gross, Uwe ^{[5
]}

Pleyer, Uwe ^{[6
]}

Lueder, Carsten ^{[5
]}

机构：

[1] Univ Magdeburg, Inst Med Microbiol Infect Control & Prevent, D-39106 Magdeburg, Germany

[2] Helmholtz Ctr Infect Res, Braunschweig, Germany

[3] Univ Dusseldorf, Inst Med Microbiol & Hosp Hyg, Dusseldorf, Germany

[4] Friedrich Loeffler Inst, Inst Epidemiol, Greifswald, Germany

[5] Univ Med Ctr, Inst Med Microbiol, Gottingen, Germany

[6] Charite, Eye Clin, D-13353 Berlin, Germany

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2014年 / 304卷 / 07期

关键词：

Toxoplasma; Zoonotic infection; Epidemiology; Toxoplasma eye infection; Congenital toxoplasmosis; GOLDMANN-WITMER COEFFICIENT; POLYMERASE-CHAIN-REACTION; NEOSPORA-CANINUM ANTIBODIES; IMMUNITY-RELATED GTPASES; SKELETAL-MUSCLE CELLS; FREE-RANGE CHICKENS; BOARS SUS-SCROFA; GONDII INFECTION; RISK-FACTORS; CONGENITAL TOXOPLASMOSIS;

D O I：

10.1016/j.ijmm.2014.09.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Toxoplasma gondii is an extremely sucessfull protozoal parasite which infects almost all mamalian species including humans. Approximately 30% of the human population worldwide is chronically infected with T. gondii. In general, human infection is asymptomatic but the parasite may induce severe disease in fetuses and immunocompromised patients. In addition, T. gondii may cause sight-threatening posterior uveitis in immunocompetent patients. Apart from few exceptions, humans acquire T. gondii from animals. Both, the oral uptake of T. gondii oocysts released by specific hosts, i.e. felidae, and of cysts persisting in muscle cells of animals result in human toxoplasmosis. In the present review, we discuss recent new data on the cell biology of T. gondii and parasite diversity in animals. In addition, we focus on the impact of these various parasite strains and their different virulence on the clinical outcome of human congenital toxoplasmosis and T. gondii uveitis. (C) 2014 Elsevier GmbH. All rights reserved.

引用

页码：917 / 929

页数：13

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