A titanium-catalyzed three-component coupling to generate α,β-unsaturated β-iminoamines

被引：123

作者：

Cao, CS ^{[1
]}

Shi, YH ^{[1
]}

Odom, AL ^{[1
]}

机构：

[1] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 10期

关键词：

D O I：

10.1021/ja0284714

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The three-component coupling of an amine, alkyne, and isonitrile is facilitated by a titanium complex bearing the N,N-di(pyrrolyl-α-methyl)-N-methylamine (dpma) ligand. From this methodology, α,β-unsaturated β-iminoamines are generated regioselectively with many substrates and are available on multigram scales. Copyright © 2003 American Chemical Society.

引用

页码：2880 / 2881

页数：2

共 47 条

[31]

2-7

[32] Reactivity of a terminal Ti(IV) imido complex toward alkenes and alkynes: Cycloaddition vs C-H activation [J].

Polse, JL ;

Andersen, RA ;

Bergman, RG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (51) :13405-13414

[33] SYNTHETIC REACTIONS BY COMPLEX CATALYST .20. COPPER(I)CATALYZED FORMIMIDATION OF AMINE, ALCOHOL, AND AMIDE BY VINYL ISOCYANIDE [J].

SAEGUSA, T ;

MURASE, I ;

ITO, Y .

JOURNAL OF ORGANIC CHEMISTRY, 1971, 36 (19) :2876-&

[34] Target-oriented and diversity-oriented organic synthesis in drug discovery [J].

Schreiber, SL .

SCIENCE, 2000, 287 (5460) :1964-1969

[35] Ti(NMe2)4 as a precatalyst for hydroamination of alkynes with primary amines [J].

Shi, YH ;

Ciszewski, JT ;

Odom, AL .

ORGANOMETALLICS, 2001, 20 (19) :3967-3969

[36]

Siebeneicher H, 2002, EUR J ORG CHEM, V2002, P1213, DOI 10.1002/1099-0690(200204)2002:7<1213::AID-EJOC1213>3.0.CO

[37]

2-G

[38]

Sieibeneicher H, 2000, J PRAK CHEM-CHEM ZTG, V342, P102

[39] Stepwise reduction of dinitrogen bond order by a low-coordinate iron complex [J].

Smith, JM ;

Lachicotte, RJ ;

Pittard, KA ;

Cundari, TR ;

Lukat-Rodgers, G ;

Rodgers, KR ;

Holland, PL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (37) :9222-9223

[40] Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform [J].

Spring, DR ;

Krishnan, S ;

Blackwell, HE ;

Schreiber, SL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (07) :1354-1363

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