A twin-pronged attack on complex traits

被引：477

作者：

Martin, N

Boomsma, D

Machin, G

机构：

[1] FREE UNIV AMSTERDAM,DEPT PSYCHOL,AMSTERDAM,NETHERLANDS

[2] PERMANENTE MED GRP INC,NO CALIF REG,OAKLAND,CA

来源：

NATURE GENETICS | 1997年 / 17卷 / 04期

关键词：

D O I：

10.1038/ng1297-387

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Before one starts the hunt for quantitative trait loci (QTLs) for a complex trait, it is necessary to show that the trait is genetically influenced. This evidence is most likely to come from the classical twin study-the demonstration that monozygotic twins are more similar for the trait than dizygotic twins. The strengths and weaknesses of twin studies are discussed, and it is suggested that, far from becoming irrelevant with advances in molecular biology, they can improve the efficiency of QTL detection and play an important role in unravelling developmental genetic mechanisms.

引用

页码：387 / 392

页数：6

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