Stonins - Specialized Adaptors for Synaptic Vesicle Recycling and Beyond?

被引：36

作者：

Maritzen, Tanja ^{[1
,2
]}

Podufall, Jasmin ^{[1
,2
]}

Haucke, Volker ^{[1
,2
,3
]}

机构：

[1] Free Univ Berlin, Dept Membrane Biochem, Inst Chem & Biochem, D-1000 Berlin, Germany

[2] Charite, D-13353 Berlin, Germany

[3] Leibniz Inst Mol Pharmacol, Sect Signal Transduct & Mol Genet, D-14195 Berlin, Germany

来源：

TRAFFIC | 2010年 / 11卷 / 01期

关键词：

clathrin adaptor AP-2; endocytosis; Eps15; stonin; synaptic vesicles; synaptotagmin; ENDOCYTIC SORTING ADAPTER; STONED LOCUS; DROSOPHILA-MELANOGASTER; FUNCTIONAL DISSECTION; SYNAPTOTAGMIN MUTANTS; TRANSMITTER RELEASE; MEMBRANE CURVATURE; C2B DOMAIN; PROTEINS; AP-2;

D O I：

10.1111/j.1600-0854.2009.00971.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stonins are a small family of evolutionarily conserved clathrin adaptor complex AP-2 mu-related factors that may act as cargo-specific sorting adaptors in endocytosis and perhaps beyond. Whereas little is known about the localization and function of stonin 1, recent work suggests that stonin 2 serves as a linker between the endocytic proteins AP-2 and Eps15 and the calcium-sensing synaptic vesicle (SV) protein synaptotagmin 1. The molecular determinants involved in the recognition of SV cargo by the mu-homology domain of stonin 2 are evolutionarily conserved from worm to man, thereby identifying stonin 2 and its invertebrate homologs uncoordinated (UNC)-41 and stoned B as endocytic adaptors dedicated to the retrieval of surface-stranded SV proteins, most notably synaptotagmin. In this review, we summarize the current state of knowledge about mammalian stonins with a special focus on the role of stonin 2 in SV recycling at presynaptic nerve terminals.

引用

页码：8 / 15

页数：8

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