An exercise-based randomized controlled trial on brain, cognition, physical health and mental health in overweight/obese children (ActiveBrains project): Rationale, design and methods

被引：92

作者：

Cadenas-Sanchez, Cristina ^{[1
]}

Mora-Gonzalez, Jose ^{[1
]}

Migueles, Jairo H. ^{[1
]}

Martin-Matillas, Miguel ^{[1
]}

Gomez-Vida, Jose ^{[2
]}

Victoria Escolano-Margarit, Maria ^{[2
]}

Maldonado, Jose ^{[3
,4
]}

Maria Enriquez, Gala ^{[1
]}

Pastor-Villaescusa, Belen ^{[5
,6
]}

de Teresa, Carlos ^{[7
]}

Navarrete, Socorro ^{[7
]}

Maria Lozano, Rosa ^{[7
]}

de Dios Beas-Jimenez, Juan ^{[7
]}

Estevez-Lopez, Fernando ^{[8
,9
]}

Mena-Molina, Alejandra ^{[1
]}

Jose Heras, Maria ^{[10
]}

Chillon, Palma ^{[1
]}

Campoy, Cristina ^{[11
]}

Munoz-Hernandez, Victoria ^{[1
]}

Daniela Martinez-Avila, Wendy ^{[1
]}

Elisa Merchan, Maria ^{[1
]}

Perales, Jose C. ^{[12
,13
]}

Gil, Angel ^{[5
,6
]}

Verdejo-Garcia, Antonio ^{[13
,14
,15
,16
]}

Aguilera, Concepcion M. ^{[5
,6
]}

Ruiz, Jonatan R. ^{[1
,17
]}

Labayen, Idoia ^{[18
]}

Catena, Andres ^{[12
]}

Ortega, Francisco B. ^{[1
,17
]}

机构：

[1] Univ Granada, PROFITH PROmoting FITness & Hlth Phys Act Res Grp, Dept Phys Educ & Sports, Fac Sport Sci, E-18071 Granada, Spain

[2] San Cecilio Hosp, Dept Pediat, Granada, Spain

[3] Univ Granada, Dept Pediat, Sch Med, E-18071 Granada, Spain

[4] Inst Invest Biosanitaria IBS, Inst Biomed Res, Granada, Spain

[5] Univ Granada, Dept Biochem & Mol Biol 2, Inst Nutr & Food Technol, Ctr Biomed Res, E-18071 Granada, Spain

[6] CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain

[7] Andalusian Ctr Sport Med CAMD, Junta De Andalucia, Spain

[8] Univ Granada, Dept Phys Educ & Sport, Fac Sport Sci, E-18071 Granada, Spain

[9] Univ Utrecht, Fac Social & Behav Sci, Dept Psychol, Utrecht, Netherlands

[10] Materno Infantil Hosp, Granada, Spain

[11] Univ Granada, EURISTIKOS Excellence Ctr Paediat Res, E-18071 Granada, Spain

[12] Univ Granada, Mind Brain & Behav Res Ctr CIMCYC, E-18071 Granada, Spain

[13] Univ Granada, Dept Expt Psychol, E-18071 Granada, Spain

[14] Univ Granada, Inst Neurosci F Oloriz, E-18071 Granada, Spain

[15] Monash Univ, Sch Psychol Sci, Melbourne, Vic 3004, Australia

[16] Monash Univ, Monash Inst Cognit & Clin Neurosci, Melbourne, Vic 3004, Australia

[17] Karolinska Inst, Dept Biosci & Nutr, Huddinge, Sweden

[18] Univ Basque Country, Dept Nutr & Food Sci, UPV EHU, Vitoria, Spain

来源：

CONTEMPORARY CLINICAL TRIALS | 2016年 / 47卷

关键词：

Physical activity; Magnetic imaging resonance; Academic performance; Personality; Behaviour; Preadolescents; CHILDHOOD AEROBIC FITNESS; R-R INTERVALS; SPANISH VERSION; CARDIORESPIRATORY FITNESS; AUTOMATED QUANTITATION; PSYCHOLOGICAL STRESS; METABOLIC RISK; POLAR S810; SCALE; ADOLESCENTS;

D O I：

10.1016/j.cct.2016.02.007

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The new and recent advances in neuroelectric and neuroimaging technologies provide a new era for further exploring and understanding how brain and cognition function can be stimulated by environmental factors, such as exercise, and particularly to study whether physical exercise influences brain development in early ages. The present study, namely the ActiveBrains project, aims to examine the effects of a physical exercise programme on brain and cognition, as well as on selected physical and mental health outcomes in overweight/obese children. A total of 100 participants aged 8 to 11 years are randomized into an exercise group (N = 50) or a control group (N = 50). The intervention lasts 20-weeks, with 3-5 sessions per week of 90 min each, and is mainly focused on high intensity aerobic exercise yet also includes muscle-strengthening exercises. The extent to what the intervention effect remains 8-months after the exercise programme finishes is also studied in a subsample. Brain structure and function and cognitive performance are assessed using structural and functional magnetic resonance imaging and electroencephalographic recordings. Secondary outcomes include physical health outcomes (e.g. physical fitness, body fatness, bone mass and lipid-metabolic factors) and mental health outcomes (e.g. chronic stress indicators and overall behavioural and personality measurements such as anxiety or depression). This project will substantially contribute to the existing knowledge and will have an impact on societies, since early stimulation of brain development might have long lasting consequences on cognitive performance, academic achievement and in the prevention of behavioural problems and the promotion of psychological adjustment and mental health. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：315 / 324

页数：10

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