Kinesin-1 plays a role in transport of SNAP-25 to the plasma membrane

被引：10
|
作者：
Morton, April M.
Cunningham, Anthony L.
Diefenbach, Russell J. [1 ]
机构：
[1] Univ Sydney, Westmead Millennium Inst, Ctr Virus Res, Westmead, NSW 2145, Australia
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 391卷 / 01期
基金：
英国医学研究理事会;
关键词：
Kinesin-1; KIF5B; SNAP-25; Trafficking; Transport; HEAVY-CHAIN; CONVENTIONAL KINESIN; LIGHT-CHAIN; ANTEROGRADE TRANSPORT; AXONAL-TRANSPORT; TERMINAL DOMAIN; BINDING DOMAIN; CARGO-BINDING; PROTEIN; LOCALIZATION;
D O I：
10.1016/j.bbrc.2009.11.068
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cellular molecular motor kinesin-1 mediates the microtubule-dependent transport of a range of cargo. We have previously identified an interaction between the cargo-binding domain of kinesin-1 heavy chain KIF5B and the membrane-associated SNARE proteins SNAP-25 and SNAP-23. In this study we further defined the minimal SNAP-25 binding domain in KIF5B to residues 874-894 Overexpression of a fragment of KIF5B (residues 594-910) resulted in significant colocalization with SNAP-25 with resulting blockage of the trafficking of SNAP-25 to the periphery of cells This indicates that kinesin-1 facilitates the transport of SNAP-25 containing vesicles as a prerequisite to SNAP-25 driven membrane fusion events (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：388 / 393
页数：6
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