Kinesin-1 plays a role in transport of SNAP-25 to the plasma membrane

被引：10
|
作者：
Morton, April M.
Cunningham, Anthony L.
Diefenbach, Russell J. [1 ]
机构：
[1] Univ Sydney, Westmead Millennium Inst, Ctr Virus Res, Westmead, NSW 2145, Australia
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 391卷 / 01期
基金：
英国医学研究理事会;
关键词：
Kinesin-1; KIF5B; SNAP-25; Trafficking; Transport; HEAVY-CHAIN; CONVENTIONAL KINESIN; LIGHT-CHAIN; ANTEROGRADE TRANSPORT; AXONAL-TRANSPORT; TERMINAL DOMAIN; BINDING DOMAIN; CARGO-BINDING; PROTEIN; LOCALIZATION;
D O I：
10.1016/j.bbrc.2009.11.068
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cellular molecular motor kinesin-1 mediates the microtubule-dependent transport of a range of cargo. We have previously identified an interaction between the cargo-binding domain of kinesin-1 heavy chain KIF5B and the membrane-associated SNARE proteins SNAP-25 and SNAP-23. In this study we further defined the minimal SNAP-25 binding domain in KIF5B to residues 874-894 Overexpression of a fragment of KIF5B (residues 594-910) resulted in significant colocalization with SNAP-25 with resulting blockage of the trafficking of SNAP-25 to the periphery of cells This indicates that kinesin-1 facilitates the transport of SNAP-25 containing vesicles as a prerequisite to SNAP-25 driven membrane fusion events (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：388 / 393
页数：6
相关论文
共 50 条
  • [21] Regulation of axonal transport of app cargos by kinesin-1
    Suzuki, T.
    Chiba, K.
    Hata, S.
    JOURNAL OF NEUROCHEMISTRY, 2015, 134 : 329 - 330
  • [22] The plasma membrane protein SNAP-25, but not syntaxin, is present at photoreceptor and bipolar cell synapses in the rat retina
    Brandstatter, JH
    Wassle, H
    Betz, H
    Morgans, CW
    EUROPEAN JOURNAL OF NEUROSCIENCE, 1996, 8 (04) : 823 - 828
  • [23] Molecular mechanism for kinesin-1 direct membrane recognition
    Anton, Zurine
    Weijman, Johannes F.
    Williams, Christopher
    Moody, Edmund R. R.
    Mantell, Judith
    Yip, Yan Y.
    Cross, Jessica A.
    Williams, Tom A.
    Steiner, Roberto A.
    Crump, Matthew P.
    Woolfson, Derek N.
    Dodding, Mark P.
    SCIENCE ADVANCES, 2021, 7 (31)
  • [24] A dual role of SNAP-25 as carrier and guardian of synaptic transmission
    Kochlamazashvili, Gaga
    Haucke, Volker
    EMBO REPORTS, 2013, 14 (07) : 579 - 580
  • [25] Evidence Of A Role For SNAP-25 As A v-SNARE In Vitro
    Forbes, Brandon E.
    La Monica, Nathan C.
    Edwards, Gary R.
    Woodbury, Dixon J.
    BIOPHYSICAL JOURNAL, 2009, 96 (03) : 100A - 100A
  • [26] Regulated axonal transport of APP and alcadein by kinesin-1
    Suzuki, Toshiharu
    Chiba, Kyoko
    Okumura, Yuka
    Shiraki, Yuzuha
    Sobu, Yuriko
    Kinjo, Masataka
    Hata, Saori
    Taru, Hidenori
    FASEB JOURNAL, 2014, 28 (01):
  • [27] Munc18-1 is critical for plasma membrane localization of syntaxin1 but not of SNAP-25 in PC12 cells
    Arunachalam, Lakshmanan
    Han, Liping
    Tassew, Nardos G.
    He, Yu
    Wang, Li
    Xie, Li
    Fujita, Yoshihito
    Kwan, Edwin
    Davletov, Bazbek
    Monnier, Philippe P.
    Gaisano, Herbert Y.
    Sugita, Shuzo
    MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (02) : 722 - 734
  • [28] Recycling of Kinesin-1 Motors by Diffusion after Transport
    Blasius, T. Lynne
    Reed, Nathan
    Slepchenko, Boris M.
    Verhey, Kristen J.
    PLOS ONE, 2013, 8 (09):
  • [29] Motor Domain Phosphorylation Modulates Kinesin-1 Transport
    DeBerg, Hannah A.
    Blehm, Benjamin H.
    Sheung, Janet
    Thompson, Andrew R.
    Bookwalter, Carol S.
    Torabi, Seyed F.
    Schroer, Trina A.
    Berger, Christopher L.
    Lu, Yi
    Trybus, Kathleen M.
    Selvin, Paul R.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (45) : 32612 - 32621
  • [30] Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD
    J Mill
    S Richards
    J Knight
    S Curran
    E Taylor
    P Asherson
    Molecular Psychiatry, 2004, 9 : 801 - 810
12345