99mTc-sestamibi SPECT/CT for the characterization of renal masses: a pictorial guide

被引：26

作者：

Campbell, Scott P. ^{[1
,2
]}

Tzortzakakis, Antonios ^{[3
]}

Javadi, Mehrbod S. ^{[4
]}

Karlsson, Mattias ^{[5
]}

Solnes, Lilja B. ^{[4
]}

Axelsson, Rimma ^{[6
]}

Allaf, Mohamad E. ^{[1
,2
]}

Gorin, Michael A. ^{[1
,2
]}

Rowe, Steven P. ^{[1
,2
,4
]}

机构：

[1] Johns Hopkins Univ, Sch Med, James Buchanan Brady Urol Inst, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Sch Med, Dept Urol, Baltimore, MD 21205 USA

[3] Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Imaging & Funct, Stockholm, Sweden

[4] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21218 USA

[5] Karolinska Univ Hosp, Med Phys & Nucl Med, Imaging & Funct, Stockholm, Sweden

[6] Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Imaging & Funct,Med Phys & Nucl Med, Stockholm, Sweden

来源：

BRITISH JOURNAL OF RADIOLOGY | 2018年 / 91卷 / 1084期

关键词：

CELL CARCINOMA; EPITHELIAL NEOPLASMS; TC-99M-MIBI SPECT/CT; DIAGNOSTIC-ACCURACY; P-GLYCOPROTEIN; UNITED-STATES; BIOPSY; DIFFERENTIATION; CANCER; TUMORS;

D O I：

10.1259/bjr.20170526

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In parallel to the increased utilization of cross-sectional imaging, the incidence of small renal masses has steadily risen in recent years. At the present time, anatomical imaging techniques are limited in their ability to differentiate benign from malignant renal masses, Moreover, renal mass biopsy has a high non-diagnostic rate, poor negative-predictive ability, and carries potential risks as well as substantial costs. As a result, benign renal masses are often unnecessarily resected for the false presumption of cancer. Tc-99m-sestamibi single photon emission computed tomography/ computed tomography (SPECT/CT) is a molecular imaging test that allows for the differentiation of benign renal oncocytomas and hybrid oncocytomic/chromophobe tumours apart from malignant renal cell carcinomas on the basis of differences in mitochondrial content as well as multidrug resistant pump expression. Herein, we review the principles of Tc-99m-sestamibi SPECT/CT administration and image interpretation for the purpose of renal mass characterization.

引用

页数：6

共 20 条

[1] Rising incidence of renal cell cancer in the United States [J].