Unusual bone scan of a child with osteogenesis imperfecta

An 8-year-old boy had multiple fractures and skeletal deformities. The first fracture occurred in the proximal left femur spontaneously when he was 6 months old. The clinical diagnosis was osteogenesis imperfecta (OI). Subsequently, fractures of other bones occurred spontaneously or due to minor trauma and caused him to remain confined to bed. His appearance at birth was normal. There was neither family history nor classic stigmata of OI such as blue sclerae, hearing loss, or short stature. Findings of radiographs and bone mineral density measurements were consistent with severe osteopenia.