MicroRNA-635 inhibits the malignancy of osteosarcoma by inducing apoptosis

被引：12

作者：

Tian, Linqiang ^{[1
]}

Guo, Zhihao ^{[1
]}

Wang, Hongwei ^{[1
]}

Liu, Xiaotan ^{[1
]}

机构：

[1] Xinxiang Med Univ, Affiliated Hosp 3, Dept Orthoped Surg, East Hualan Ave, Xinxiang 453003, Henan, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2017年 / 16卷 / 04期

关键词：

microRNA-635; osteosarcoma; proliferation; migration; apoptosis; CELL LUNG-CANCER; TUMOR-SUPPRESSOR; CARCINOMA-CELLS; EXPRESSION; MIGRATION; INVASION; METASTASIS; INCREASES;

D O I：

10.3892/mmr.2017.7127

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent evidence has suggested that microRNAs (miRs), which are a class of non-coding RNAs, serve diverse roles in tumorigenesis. However, the role of miR-635 in osteosarcoma (OS) remains unknown. The present study revealed that miR-635 may be a tumor suppressive miR. The expression of miR-635 was significantly decreased in OS specimens. In addition, the proliferation and invasion of OS cells transfected with miR-635 may be effectively attenuated. Transfection of cells with miR-635 may further inhibit tumor growth in vivo. miR-635 may antagonize tumorigenesis of OS possibly by inducing apoptosis, as demonstrated by flow cytometric analysis and caspase-3 kinase assays. The data of the present study suggested that miR-635 may be a novel tumor suppressor and may serve as a putative diagnostic marker for patients with OS.

引用

收藏

页码：4829 / 4834

页数：6

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