Ophthalmic follow-up of patients with tyrosinaemia type I on NTBC

被引：28

作者：

Gissen, P

Preece, MA

Willshaw, HA

McKiernan, PJ

机构：

[1] Birmingham Childrens Hosp, Liver Unit, Birmingham B4 6NH, W Midlands, England

[2] Birmingham Childrens Hosp, Dept Clin Chem, Birmingham B4 6NH, W Midlands, England

[3] Birmingham Childrens Hosp, Dept Ophthalmol, Birmingham B4 6NH, W Midlands, England

来源：

JOURNAL OF INHERITED METABOLIC DISEASE | 2003年 / 26卷 / 01期

关键词：

D O I：

10.1023/A:1024011110116

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

NTBC has revolutionized the management of tyrosinaemia type I, although animal experiments have shown that long-term administration may produce corneal opacities analogous to those in tyrosinaemia type II. We have assessed the prevalence of ocular side-effects in 11 tyrosinaemia type I patients on NTBC attending the Birmingham Children's Hospital. Despite high plasma tyrosine concentrations in some patients, they did not experience symptoms or signs of ocular toxicity.

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页码：13 / 16

页数：4

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