Rocky Mountain spotted fever in Mexican children: Clinical and mortality factors

被引：16

作者：

Alvarez-Hernandez, Gerardo ^{[1
]}

del Carmen Candia-Plata, Maria ^{[1
]}

Delgado-de la Mora, Jesus ^{[1
]}

Haydee Acuna-Melendrez, Natalia ^{[1
]}

Patricia Vargas-Ortega, Anabel ^{[1
]}

David Licona-Enriquez, Jesus ^{[1
]}

机构：

[1] Univ Sonora, Dept Med & Ciencias Salud, Blvd Luis D Colosio S-N, Hermosillo 83000, Sonora, Mexico

来源：

SALUD PUBLICA DE MEXICO | 2016年 / 58卷 / 03期

关键词：

Rocky Mountain spotted fever; children; adolescents; Mexico; HEALTH-CARE PROVIDERS; ACUTE-RENAL-FAILURE; UNITED-STATES; RICKETTSIOSES; GUIDELINES; PREDICTORS; DIAGNOSIS; ARIZONA; DOGS;

D O I：

10.21149/spm.v58i3.7908

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective. Characterize clinical manifestations and predictors of mortality in children hospitalized for spotted fever. Materials and methods. Cross-sectional study in 210 subjects with a diagnosis of Rocky Mountain spotted fever (RMSF) in a pediatric hospital in Sonora, from January 1st, 2004 to June 30th, 2015. Data were analyzed using descriptive statistics and multivariate logistic regression. Results. An upward trend was observed in RMSF morbidity and mortality. Fatality rate was 30%.Three predictors were associated with risk of death: delay 5 days at the start of doxycycline (ORa = 2.95, 95% CI 1.10-7.95), acute renal failure ((ORa, = 8.79, 95% CI 3.46-22.33) and severe sepsis (ORa, = 3.71,95% CI 1.44-9.58). Conclusions. RMSF causes high mortality in children, which can be avoided with timely initiation of doxycycline. Acute renal failure and severe sepsis are two independent predictors of death in children with RMSF.

引用

页码：385 / 392

页数：8

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